Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells

被引：6

作者：

Liu, Yuan ^{[1
]}

Zhang, Yueling ^{[1
]}

Gu, Zhaohui ^{[1
]}

Hao, Lina ^{[2
]}

Du, Juan ^{[1
]}

Yang, Qian ^{[1
]}

Li, Suping ^{[1
]}

Wang, Liying ^{[1
]}

Gong, Shilei ^{[3
]}

机构：

[1] First Cent Hosp Baoding, Dept Ophthalmol, Baoding, Hebei Province, Peoples R China

[2] Hebei Prov Peoples Hosp, Dept Ophthalmol, Shijiazhuang, Hebei Province, Peoples R China

[3] First Cent Hosp Baoding, Dept Endoscope Room, Baoding, Hebei Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 14期

关键词：

nerve regeneration; retinal pigment epithelial cells; peroxynitrite; cholecystokinin octapeptide; apoptosis; Fas-associated death domain; Bax; Caspase-8; Bcl-2; neural regeneration; INDUCED OXIDATIVE STRESS; DEATH DOMAIN PROTEIN; NITRIC-OXIDE SYNTHASE; MACULAR DEGENERATION; UP-REGULATION; PEROXYNITRITE; EXPRESSION; PATHWAY; COMPLEX; FADD;

D O I：

10.4103/1673-5374.137596

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspase-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite.

引用

页码：1402 / 1408

页数：7

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