DDX47 promotes cell proliferation and migration in lung adenocarcinoma

被引：2

作者：

Chen, Yang ^{[1
]}

Zeng, Lizhong ^{[1
]}

Wang, Wei ^{[2
]}

Yuan, Jingyan ^{[1
]}

Sun, Ruiying ^{[1
]}

Yang, Shuanying ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Phys Examinat, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 234卷

关键词：

Lung adenocarcinoma; DDX47; Proliferation; Migration; CANCER; APOPTOSIS;

D O I：

10.1016/j.prp.2022.153921

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This study aimed to investigate the role of DEAD-box helicase 47 (DDX47) in lung adenocarcinoma (LUAD). Our results demonstrated that DDX47 was highly expressed in LUAD tissues, and its high expression predicted a poor prognosis. Bioinformatics analysis indicated that DDX47 involved RNA processing and cell division. Furthermore, knockdown of DDX47 reduced cell proliferation and migration in vitro. In sum, our data confirmed the cancer-promoting effect of DDX47.

引用

页数：8

共 22 条

[1] cytoHubba: identifying hub objects and sub-networks from complex interactome [J].

Chin, Chia-Hao ;

Chen, Shu-Hwa ;

Wu, Hsin-Hung ;

Ho, Chin-Wen ;

Ko, Ming-Tat ;

Lin, Chung-Yen .

BMC SYSTEMS BIOLOGY, 2014, 8

[2] The DEAD-box protein family of RNA helicases [J].

Cordin, O ;

Banroques, J ;

Tanner, NK ;

Linder, P .

GENE, 2006, 367 :17-37

[3] The plasma peptides of breast versus ovarian cancer [J].

Dufresne, Jaimie ;

Bowden, Pete ;

Thavarajah, Thanusi ;

Florentinus-Mefailoski, Angelique ;

Chen, Zhuo Zhen ;

Tucholska, Monika ;

Norzin, Tenzin ;

Ho, Margaret Truc ;

Phan, Morla ;

Mohamed, Nargiz ;

Ravandi, Amir ;

Stanton, Eric ;

Slutsky, Arthur S. ;

dos Santos, Claudia C. ;

Romaschin, Alexander ;

Marshall, John C. ;

Addison, Christina ;

Malone, Shawn ;

Heyland, Daren ;

Scheltens, Philip ;

Killestein, Joep ;

Teunissen, Charlotte ;

Diamandis, Eleftherios P. ;

Siu, K. W. M. ;

Marshall, John G. .

CLINICAL PROTEOMICS, 2019, 16 (01)

[4] Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma [J].

Gillette, Michael A. ;

Satpathy, Shankha ;

Cao, Song ;

Dhanasekaran, Saravana M. ;

Vasaikar, Suhas V. ;

Krug, Karsten ;

Petralia, Francesca ;

Li, Yize ;

Liang, Wen-Wei ;

Reva, Boris ;

Krek, Azra ;

Ji, Jiayi ;

Song, Xiaoyu ;

Liu, Wenke ;

Hong, Runyu ;

Yao, Lijun ;

Blumenberg, Lili ;

Savage, Sara R. ;

Wendl, Michael C. ;

Wen, Bo ;

Li, Kai ;

Tang, Lauren C. ;

MacMullan, Melanie A. ;

Avanessian, Shayan C. ;

Kane, M. Harry ;

Newton, Chelsea J. ;

Cornwell, MacIntosh ;

Kothadia, Ramani B. ;

Ma, Weiping ;

Yoo, Seungyeul ;

Mannan, Rahul ;

Vats, Pankaj ;

Kumar-Sinha, Chandan ;

Kawaler, Emily A. ;

Omelchenko, Tatiana ;

Colaprico, Antonio ;

Geffen, Yifat ;

Maruvka, Yosef E. ;

Leprevost, Felipe da Veiga ;

Wiznerowicz, Maciej ;

Gumus, Zeynep H. ;

Veluswamy, Rajwanth R. ;

Hostetter, Galen ;

Heiman, David, I ;

Wyczalkowski, Matthew A. ;

Hiltke, Tara ;

Mesri, Mehdi ;

Kinsinger, Christopher R. ;

Boja, Emily S. ;

Omenn, Gilbert S. .

CELL, 2020, 182 (01) :200-+

[5] GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47) [J].

Lee, JH ;

Rho, SB ;

Chun, T .

BIOTECHNOLOGY LETTERS, 2005, 27 (09) :623-628

[6] Amentoflavone induces cell cycle arrest, apoptosis, and autophagy in BV-2 cells [J].

Liu, Zheng ;

Wang, Feng ;

Ma, Hui ;

Xia, Hechun ;

Tian, Jihui ;

Sun, Tao .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2020, 25 :798-816

[7] 18S rRNA processing requires the RNA helicase-like protein Rrp3 [J].

ODay, CL ;

Chavanikamannil, F ;

Abelson, J .

NUCLEIC ACIDS RESEARCH, 1996, 24 (16) :3201-3207

[8] The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data [J].

Oehler, Vivian G. ;

Yeung, Ka Yee ;

Choi, Yongjae E. ;

Bumgarner, Roger E. ;

Raftery, Adrian E. ;

Radich, Jerald P. .

BLOOD, 2009, 114 (15) :3292-3298

[9] FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress [J].

Okamoto, Yusuke ;

Abe, Masako ;

Itaya, Akiko ;

Tomida, Junya ;

Ishiai, Masamichi ;

Takaori-Kondo, Akifumi ;

Taoka, Masato ;

Isobe, Toshiaki ;

Takata, Minoru .

FEBS JOURNAL, 2019, 286 (01) :139-150

[10] Integral Analysis of the RNA Binding Protein-associated Prognostic Model for Renal Cell Carcinoma [J].

Qin, Xin ;

Liu, Zhengfang ;

Yan, Keqiang ;

Fang, Zhiqing ;

Fan, Yidong .

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2021, 18 (04) :953-963

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