CuBr-Promoted Formal Hydroacylation of 1-Alkynes with Glyoxal Derivatives: An Unexpected Synthesis of 1,2-Dicarbonyl-3-enes

被引：28

作者：

Chen, Shufeng ^{[1
]}

Li, Xiaojie ^{[1
]}

Zhao, Haiying ^{[1
]}

Li, Baoguo ^{[1
]}

机构：

[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Hohhot 010021, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ALDEHYDE-ALKYNE-AMINE; TERMINAL ALKYNES; FACILE SYNTHESES; 1,2-DIKETONES; HOMOLOGATION; OXIDATION; ALKENYL;

D O I：

10.1021/jo500199v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and concise protocol has been developed for the highly regio- and stereoselective synthesis of E-1,2-dicarbonyl-3-ene derivatives by a copper-promoted reaction of 1-alkynes with a-carbonyl aldehydes in the presence of morpholine. The products obtained are believed as the formal hydroacylation of the triple bond.

引用

页码：4137 / 4141

页数：5

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