Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

被引：140

作者：

Ntoutoume, Gautier M. A. Ndong ^{[1
]}

Granet, Robert ^{[1
]}

Mbakidi, Jean Pierre ^{[1
]}

Bregier, Frederique ^{[1
]}

Leger, David Y. ^{[1
]}

Fidanzi-Dugas, Chloe ^{[1
]}

Lequart, Vincent ^{[2
]}

Joly, Nicolas ^{[2
]}

Liagre, Bertrand ^{[1
]}

Chaleix, Vincent ^{[1
]}

Sol, Vincent ^{[1
]}

机构：

[1] Univ Limoges, Lab Chim Subst Nat, EA 1069, F-87000 Limoges, France

[2] Univ Artois, IUT Bethune, 1230 Rue Univ, F-62408 Bethune, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 03期

关键词：

Cellulose nanocrystals; Nanoparticles; Curcumin; Drug delivery; Cancer cells; MODIFIED CELLULOSE NANOCRYSTALS; IN-VITRO; NANOPARTICLES; CELLS; TUMOR;

D O I：

10.1016/j.bmcl.2015.12.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic beta-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/ CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC(50)s lower than that of curcumin alone. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：941 / 945

页数：5

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