Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

被引：140
作者：
Ntoutoume, Gautier M. A. Ndong [1 ]
Granet, Robert [1 ]
Mbakidi, Jean Pierre [1 ]
Bregier, Frederique [1 ]
Leger, David Y. [1 ]
Fidanzi-Dugas, Chloe [1 ]
Lequart, Vincent [2 ]
Joly, Nicolas [2 ]
Liagre, Bertrand [1 ]
Chaleix, Vincent [1 ]
Sol, Vincent [1 ]
机构：
[1] Univ Limoges, Lab Chim Subst Nat, EA 1069, F-87000 Limoges, France
[2] Univ Artois, IUT Bethune, 1230 Rue Univ, F-62408 Bethune, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 03期
关键词：
Cellulose nanocrystals; Nanoparticles; Curcumin; Drug delivery; Cancer cells; MODIFIED CELLULOSE NANOCRYSTALS; IN-VITRO; NANOPARTICLES; CELLS; TUMOR;
D O I：
10.1016/j.bmcl.2015.12.060
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic beta-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/ CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC(50)s lower than that of curcumin alone. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：941 / 945
页数：5
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