Stimuli-Responsive Cucurbit[7] uril-Mediated BSA Nanoassembly for Uptake and Release of Doxorubicin

被引：46

作者：

Barooah, Nilotpal ^{[1
]}

Kunwar, Amit ^{[1
]}

Khurana, Raman ^{[1
,2
]}

Bhasikuttan, Achikanath C. ^{[1
,2
]}

Mohanty, Jyotirmayee ^{[1
,2
]}

机构：

[1] Bhabha Atom Res Ctr, Radiat & Photochem Div, Bombay 400085, Maharashtra, India

[2] Homi Bhabha Natl Inst, Training Sch Complex, Bombay 400094, Maharashtra, India

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 01期

关键词：

cytotoxicity; drug delivery; host-guest systems; macrocyclic host; recognition-mediated nanoassembly; supramolecular chemistry; FACILE SUPRAMOLECULAR STRATEGY; TIME-RESOLVED FLUORESCENCE; MOLECULAR RECOGNITION; CUCURBITURIL; HOST; INSULIN; NANOPARTICLES; MACROCYCLES; INHIBITION; EMISSION;

D O I：

10.1002/asia.201601411

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the construction of a non-toxic nano-assembly of bovine serum albumin (BSA) protein and the cucurbit[7] uril macrocycle as well as its stimuli-responsive breakage with adamantylamine or pH, which restores the protein structure and recognition properties. The assembly showed efficient loading and controlled release of a standard drug, doxorubicin (DOX), and the same was validated in live cells. The cell viability studies documented that the DOX-loaded assembly mask the cytotoxicity of DOX and the toxicity can be revived at the target on demand, triggering its therapeutic activation. This is found to be more effective in the cancer cells. In addition, such host-assisted protein assemblies are also highly promising for stabilizing/protecting the native protein structure, a viable approach to prevent/inhibit protein misfolding and aggregation.

引用

页码：122 / 129

页数：8

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