Human Stem Cells for Modeling Heart Disease and for Drug Discovery

被引：165
作者：
Matsa, Elena [1 ,2 ,3 ]
Burridge, Paul W. [1 ,2 ,3 ]
Wu, Joseph C. [1 ,2 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 239期
基金：
美国国家卫生研究院;
关键词：
LONG-QT SYNDROME; HUMAN FIBROBLASTS; CARDIOVASCULAR PROGENITORS; CARDIOMYOCYTES; MATURATION; MYOCARDIUM; INDUCTION; MYOCYTES;
D O I：
10.1126/scitranslmed.3008921
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.
引用
收藏
页数：7
相关论文
共 56 条
[41]   Cardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis [J].
Perino, Maria Grazia ;
Yamanaka, Satoshi ;
Li, Jinliang ;
Wobus, Anna M. ;
Boheler, Kenneth R. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 45 (04) :475-494
[42]   Current status of drug screening and disease modelling in human pluripotent stem cells [J].
Rajamohan, Divya ;
Matsa, Elena ;
Kalra, Spandan ;
Crutchley, James ;
Patel, Asha ;
George, Vinoj ;
Denning, Chris .
BIOESSAYS, 2013, 35 (03) :281-298
[43]   Embryoid body morphology influences diffusive transport of inductive biochemicals: A strategy for stem cell differentiation [J].
Sachlos, Eleftherios ;
Auguste, Debra T. .
BIOMATERIALS, 2008, 29 (34) :4471-4480
[44]   Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology [J].
Schaaf, Sebastian ;
Shibamiya, Aya ;
Mewe, Marco ;
Eder, Alexandra ;
Stoehr, Andrea ;
Hirt, Marc N. ;
Rau, Thomas ;
Zimmermann, Wolfram-Hubertus ;
Conradi, Lenard ;
Eschenhagen, Thomas ;
Hansen, Arne .
PLOS ONE, 2011, 6 (10)
[45]   In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels [J].
Sekine, Hidekazu ;
Shimizu, Tatsuya ;
Sakaguchi, Katsuhisa ;
Dobashi, Izumi ;
Wada, Masanori ;
Yamato, Masayuki ;
Kobayashi, Eiji ;
Umezu, Mitsuo ;
Okano, Teruo .
NATURE COMMUNICATIONS, 2013, 4
[46]   Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells [J].
Siu, Chung-Wah ;
Lee, Yee-Ki ;
Ho, Jenny Chung-Yee ;
Lai, Wing-Hon ;
Chan, Yau-Chi ;
Kwong-Man Ng ;
Wong, Lai-Yung ;
Au, Ka-Wing ;
Lau, Yee-Man ;
Zhang, Jinqiu ;
Lay, Kenneth Weijian ;
Colman, Alan ;
Tse, Hung-Fat .
AGING-US, 2012, 4 (11) :803-822
[47]   A HCN4+cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells [J].
Spaeter, Daniela ;
Abramczuk, Monika K. ;
Buac, Kristina ;
Zangi, Lior ;
Stachel, Maxine W. ;
Clarke, Jonathan ;
Sahara, Makoto ;
Ludwig, Andreas ;
Chien, Kenneth R. .
NATURE CELL BIOLOGY, 2013, 15 (09) :1098-+
[48]   Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy [J].
Sun, Ning ;
Yazawa, Masayuki ;
Liu, Jianwei ;
Han, Leng ;
Sanchez-Freire, Veronica ;
Abilez, Oscar J. ;
Navarrete, Enrique G. ;
Hu, Shijun ;
Wang, Li ;
Lee, Andrew ;
Pavlovic, Aleksandra ;
Lin, Shin ;
Chen, Rui ;
Hajjar, Roger J. ;
Snyder, Michael P. ;
Dolmetsch, Ricardo E. ;
Butte, Manish J. ;
Ashley, Euan A. ;
Longaker, Michael T. ;
Robbins, Robert C. ;
Wu, Joseph C. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (130)
[49]   Induction of pluripotent stem cells from adult human fibroblasts by defined factors [J].
Takahashi, Kazutoshi ;
Tanabe, Koji ;
Ohnuki, Mari ;
Narita, Megumi ;
Ichisaka, Tomoko ;
Tomoda, Kiichiro ;
Yamanaka, Shinya .
CELL, 2007, 131 (05) :861-872
[50]   Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics [J].
Terrenoire, Cecile ;
Wang, Kai ;
Tung, Kelvin W. Chan ;
Chung, Wendy K. ;
Pass, Robert H. ;
Lu, Jonathan T. ;
Jean, Jyh-Chang ;
Omari, Amel ;
Sampson, Kevin J. ;
Kotton, Darrell N. ;
Keller, Gordon ;
Kass, Robert S. .
JOURNAL OF GENERAL PHYSIOLOGY, 2013, 141 (01) :61-72
123456