Human Stem Cells for Modeling Heart Disease and for Drug Discovery

被引：165
作者：
Matsa, Elena [1 ,2 ,3 ]
Burridge, Paul W. [1 ,2 ,3 ]
Wu, Joseph C. [1 ,2 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 239期
基金：
美国国家卫生研究院;
关键词：
LONG-QT SYNDROME; HUMAN FIBROBLASTS; CARDIOVASCULAR PROGENITORS; CARDIOMYOCYTES; MATURATION; MYOCARDIUM; INDUCTION; MYOCYTES;
D O I：
10.1126/scitranslmed.3008921
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A major research focus in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease.
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