Planar cell polarity and vertebrate organogenesis

被引：81
|
作者：
Karner, Courtney
Wharton, Keith A., Jr.
Carroll, Thomas J.
机构：
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Div Nephrol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, Dept Biol Mol, Dallas, TX 75390 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 02期
关键词：
Wnt; planar cell polarity; tissue polarity; organogenesis; convergent extension;
D O I：
10.1016/j.semcdb.2006.05.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：194 / 203
页数：10
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