RETRACTED: FOXC2 promotes colorectal cancer proliferation through inhibition of FOX03a and activation of MAPK and AKT signaling pathways (Retracted Article)

被引：61
|
作者：
Cui, Yan-Mei [1 ,2 ]
Jiang, Dan [4 ]
Zhang, Shi-Hong [3 ]
Wu, Ping [1 ,2 ]
Ye, Ya-Ping [1 ,2 ]
Chen, Cui-Min [1 ,2 ]
Tang, Na [1 ,2 ]
Liang, Li [1 ,2 ]
Li, Ting-Ting [1 ,2 ]
Qi, Lu [1 ,2 ]
Wang, Shu-Yang [1 ,2 ]
Jiao, Hong-Li [1 ,2 ]
Lin, Jie [1 ,2 ]
Ding, Yan-Qing [1 ,2 ]
Liao, Wen-Ting [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou 510275, Guangdong, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610041, Peoples R China
来源：
CANCER LETTERS | 2014年 / 353卷 / 01期
基金：
中国国家自然科学基金;
关键词：
FOXC2; Colorectal cancer; Prognosis; Nuclear localization; Proliferation; FORKHEAD TRANSCRIPTION FACTORS; CELL LUNG-CANCER; BREAST-CANCER; COLON-CANCER; EXPRESSION; METASTASIS; CYCLE; PROGRESSION; TRANSITION; P27(KIP1);
D O I：
10.1016/j.canlet.2014.07.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized. In analysis of 206 CRC specimens, we revealed that both high expression and nuclear localization of FOXC2 were correlated to aggressive characteristics and poor survival of patients with CRC. FOXC2 promoted cell proliferation through activation of MAPK and ART pathways, subsequently down-regulating p27, up-regulating cyclin D1 and p-FOXO3a. Furthermore, FOXC2 nuclear localization was required for its promotion of cell proliferation. These findings suggest that FOXC2 plays an essential role in CRC progression and may serve as a valuable clinical prognostic marker of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：87 / 94
页数：8
相关论文
共 50 条
  • [31] RETRACTED: lncRNA ILF3-AS1 promotes proliferation and metastasis of colorectal cancer cells by recruiting histone methylase EZH2 (Retracted Article)
    Hong, Sen
    Li, Shiquan
    Bi, Miaomiao
    Yu, Haiyao
    Yan, Zhenkun
    Liu, Tao
    Wang, Helei
    MOLECULAR THERAPY NUCLEIC ACIDS, 2021, 24 : 1012 - 1023
  • [32] RETRACTED: Effects of MicroRNA-206 on Osteosarcoma Cell Proliferation, Apoptosis, Migration and Invasion by Targeting ANXA2 Through the AKT Signaling Pathway (Retracted Article)
    Pan, Bao-Long
    Tong, Zong-Wu
    Wu, Ling
    Pan, Li
    Li, Jun-E
    Huang, You-Guang
    Li, Shu-De
    Du, Shi-Xun
    Li, Xu-Dong
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 45 (04) : 1410 - 1422
  • [33] RETRACTED: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway (Retracted article. See vol. 13, 2022)
    Jiao, Hong-li
    Weng, Bin-shu
    Yan, Shan-shan
    Lin, Zi-mo
    Wang, Shu-yang
    Chen, Xiao-ping
    Liang, Guang-hua
    Li, Xiao-Qing
    Zhao, Wei-yi
    Huang, Jia-Yi
    Zhang, Dan
    Zhang, Ling-jie
    Han, Fang-yi
    Li, Sheng-nan
    Chen, Li-jie
    Zhu, Jiong-hua
    He, Wen-feng
    Ding, Yan-qing
    Ye, Ya-ping
    CELL DEATH & DISEASE, 2020, 11 (07)
  • [34] RETRACTED: PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway (Retracted Article)
    Yang, Jianyi
    Gong, Xuejun
    Ouyang, Lu
    He, Wen
    Xiao, Rou
    Tan, Li
    ONCOLOGY LETTERS, 2016, 12 (02) : 1139 - 1143
  • [35] RETRACTED: Eupafolin induces apoptosis and autophagy of breast cancer cells through PI3K/AKT, MAPKs and NF-κB signaling pathways (Retracted Article)
    Wei, Jiahui
    Ding, Yu
    Liu, Xinmiao
    Liu, Qing
    Lu, Yiran
    He, Song
    Yuan, Bao
    Zhang, Jiabao
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [36] RETRACTED: Long Noncoding RNA LINC00857 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cell through miR-1306/Vimentin Axis (Retracted Article)
    Chang, Na
    Cui, Yayun
    Liang, Xue
    Han, Dan
    Zheng, Xiaomin
    Wu, Ailin
    Qian, Liting
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2021, 2021
  • [37] RETRACTED: MicroRNA-92a promotes tumor growth and suppresses immune function through activation of MAPK/ERK signaling pathway by inhibiting PTEN in mice bearing U14 cervical cancer (Retracted Article)
    Li, Zeng-Hui
    Li, Lei
    Kang, Lin-Ping
    Wang, Yan
    CANCER MEDICINE, 2018, 7 (07): : 3118 - 3131
  • [38] RETRACTED: KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway (Retracted Article)
    Zhang, Qi
    Di, Jun
    Ji, Zhiyu
    Mi, Aoning
    Li, Quanying
    Du, Xianghui
    Wang, Anpeng
    Wang, Anlian
    Qin, Changjiang
    DISEASE MARKERS, 2020, 2020
  • [39] RETRACTED ARTICLE: GPX8 is transcriptionally regulated by FOXC1 and promotes the growth of gastric cancer cells through activating the Wnt signaling pathway
    Hong Chen
    Lu Xu
    Zhi-li Shan
    Shu Chen
    Hao Hu
    Cancer Cell International, 20
  • [40] RETRACTED ARTICLE: Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways
    Yan Liu
    Tingting Bi
    Gang Wang
    Wei Dai
    Guoliang Wu
    Liqiang Qian
    Quangen Gao
    Genhai Shen
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, 388 : 295 - 304
12345