RETRACTED: FOXC2 promotes colorectal cancer proliferation through inhibition of FOX03a and activation of MAPK and AKT signaling pathways (Retracted Article)

被引：61
|
作者：
Cui, Yan-Mei [1 ,2 ]
Jiang, Dan [4 ]
Zhang, Shi-Hong [3 ]
Wu, Ping [1 ,2 ]
Ye, Ya-Ping [1 ,2 ]
Chen, Cui-Min [1 ,2 ]
Tang, Na [1 ,2 ]
Liang, Li [1 ,2 ]
Li, Ting-Ting [1 ,2 ]
Qi, Lu [1 ,2 ]
Wang, Shu-Yang [1 ,2 ]
Jiao, Hong-Li [1 ,2 ]
Lin, Jie [1 ,2 ]
Ding, Yan-Qing [1 ,2 ]
Liao, Wen-Ting [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou 510275, Guangdong, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610041, Peoples R China
来源：
CANCER LETTERS | 2014年 / 353卷 / 01期
基金：
中国国家自然科学基金;
关键词：
FOXC2; Colorectal cancer; Prognosis; Nuclear localization; Proliferation; FORKHEAD TRANSCRIPTION FACTORS; CELL LUNG-CANCER; BREAST-CANCER; COLON-CANCER; EXPRESSION; METASTASIS; CYCLE; PROGRESSION; TRANSITION; P27(KIP1);
D O I：
10.1016/j.canlet.2014.07.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized. In analysis of 206 CRC specimens, we revealed that both high expression and nuclear localization of FOXC2 were correlated to aggressive characteristics and poor survival of patients with CRC. FOXC2 promoted cell proliferation through activation of MAPK and ART pathways, subsequently down-regulating p27, up-regulating cyclin D1 and p-FOXO3a. Furthermore, FOXC2 nuclear localization was required for its promotion of cell proliferation. These findings suggest that FOXC2 plays an essential role in CRC progression and may serve as a valuable clinical prognostic marker of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：87 / 94
页数：8
相关论文
共 50 条
  • [21] RETRACTED: Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance (Retracted Article)
    Jiang, Zhipeng
    Hou, Zehui
    Liu, Wei
    Yu, Zhuomin
    Liang, Zhiqiang
    Chen, Shuang
    BIOENGINEERED, 2022, 13 (01) : 810 - 823
  • [22] RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
    Hong-li Jiao
    Bin-shu Weng
    Shan-shan Yan
    Zi-mo Lin
    Shu-yang Wang
    Xiao-ping Chen
    Guang-hua Liang
    Xiao-Qing Li
    Wei-yi Zhao
    Jia-Yi Huang
    Dan Zhang
    Ling-jie Zhang
    Fang-yi Han
    Sheng-nan Li
    Li-jie Chen
    Jiong-hua Zhu
    Wen-feng He
    Yan-qing Ding
    Ya-ping Ye
    Cell Death & Disease, 11
  • [23] RETRACTED: LINC01093 promotes proliferation and invasion of non-small cell lung cancer cells via targeting akt signaling pathway (Retracted Article)
    Wang, Z-X
    Xu, Z-N
    Sun, H-B
    Wang, Y.
    Han, Z-F
    Yu, Y.
    Han, X-L
    Yin, Y-Y
    Xu, L.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (01) : 222 - 229
  • [24] RETRACTED: TMEM60 Promotes the Proliferation and Migration and Inhibits the Apoptosis of Glioma through Modulating AKT Signaling (Retracted article. See vol. 2023, 2023)
    Wu, Jingwen
    Tang, Xinghua
    Yu, Xuejuan
    Zhang, Xiaoli
    Yang, Wenjun
    Seth, Ashima
    Yang, Qiuan
    JOURNAL OF ONCOLOGY, 2022, 2022
  • [25] RETRACTED: TPX2 gene silencing inhibits cell proliferation and promotes apoptosis through negative regulation of AKT signaling pathway in ovarian cancer (Retracted article. See vol. 122, 2021)
    Tian, Yuan
    Liu, Lian-Lian
    Guo, Dong-Mei
    Wang, Yan
    Zha, Wen-Hui
    Li, Yang
    Wu, Fu-Ju
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (09) : 7540 - 7555
  • [26] RETRACTED: MicroRNA-520a attenuates proliferation of Raji cells through inhibition of AKT1/NF-B and PERK/eIF2 signaling pathway (Retracted Article)
    Wang, Xiaojuan
    Wang, Pei
    Zhu, Yan
    Zhang, Zhi
    Zhang, Jinqian
    Wang, Hongwei
    ONCOLOGY REPORTS, 2016, 36 (03) : 1702 - 1708
  • [27] RETRACTED: MiR-497 promotes metastasis of colorectal cancer cells through Nrdp1 inhibition (Retracted article. See April, 2017)
    Jiang, Yongsheng
    Meng, Qinghua
    Qi, Jiaqin
    Shen, Haiyu
    Sun, Shaochuan
    TUMOR BIOLOGY, 2015, 36 (10) : 7641 - 7647
  • [28] RETRACTED: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway (Retracted Article)
    Hong, Xin
    Hong, Xingyu
    Zhao, Haomin
    He, Chengyan
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 33 (01)
  • [29] RETRACTED: LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway (Retracted Article)
    Xue, Dong
    Zhou, Cuixing
    Lu, Hao
    Xu, Renfang
    Xu, Xianlin
    He, Xiaozhou
    TUMOR BIOLOGY, 2016, 37 (12) : 16187 - 16197
  • [30] RETRACTED: Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand-receptor binding and therefore impairs cancer cell proliferation (Retracted Article)
    Wang, Feng
    Yang, Yong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 452 (04) : 1028 - 1033
12345