RETRACTED: FOXC2 promotes colorectal cancer proliferation through inhibition of FOX03a and activation of MAPK and AKT signaling pathways (Retracted Article)

被引：61
|
作者：
Cui, Yan-Mei [1 ,2 ]
Jiang, Dan [4 ]
Zhang, Shi-Hong [3 ]
Wu, Ping [1 ,2 ]
Ye, Ya-Ping [1 ,2 ]
Chen, Cui-Min [1 ,2 ]
Tang, Na [1 ,2 ]
Liang, Li [1 ,2 ]
Li, Ting-Ting [1 ,2 ]
Qi, Lu [1 ,2 ]
Wang, Shu-Yang [1 ,2 ]
Jiao, Hong-Li [1 ,2 ]
Lin, Jie [1 ,2 ]
Ding, Yan-Qing [1 ,2 ]
Liao, Wen-Ting [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou 510275, Guangdong, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610041, Peoples R China
来源：
CANCER LETTERS | 2014年 / 353卷 / 01期
基金：
中国国家自然科学基金;
关键词：
FOXC2; Colorectal cancer; Prognosis; Nuclear localization; Proliferation; FORKHEAD TRANSCRIPTION FACTORS; CELL LUNG-CANCER; BREAST-CANCER; COLON-CANCER; EXPRESSION; METASTASIS; CYCLE; PROGRESSION; TRANSITION; P27(KIP1);
D O I：
10.1016/j.canlet.2014.07.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized. In analysis of 206 CRC specimens, we revealed that both high expression and nuclear localization of FOXC2 were correlated to aggressive characteristics and poor survival of patients with CRC. FOXC2 promoted cell proliferation through activation of MAPK and ART pathways, subsequently down-regulating p27, up-regulating cyclin D1 and p-FOXO3a. Furthermore, FOXC2 nuclear localization was required for its promotion of cell proliferation. These findings suggest that FOXC2 plays an essential role in CRC progression and may serve as a valuable clinical prognostic marker of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：87 / 94
页数：8
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