Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

被引：37

作者：

Batie, Michael ^{[1
]}

del Peso, Luis ^{[2
]}

Rocha, Sonia ^{[1
]}

机构：

[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L697ZB, Merseyside, England

[2] Autonomous Madrid Univ, Inst Biomed Res, Dept Biochem, Arturo Duperier 4, Madrid 28029, Spain

来源：

BIOMEDICINES | 2018年 / 6卷 / 02期

基金：

英国惠康基金;

关键词：

hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF; INDUCIBLE FACTOR-I; HIF-BINDING SITES; GENE-EXPRESSION; EPIGENETIC REGULATION; CELLULAR-RESPONSE; BREAST-CANCER; SACCHAROMYCES-CEREVISIAE; HISTONE DEMETHYLASES; DNA METHYLATION; FLIM-FRET;

D O I：

10.3390/biomedicines6020047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.

引用

页数：19

共 134 条

[41] BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells
Kaeser, Matthias D.
Aslanian, Aaron
Dong, Meng-Qiu
Yates, John R., III
Emerson, Beverly M.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (47) : 32254 - 32263
[42] Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin
Kakarougkas, Andreas
Ismail, Amani
Chambers, Anna L.
Riballo, Enriqueta
Herbert, Alex D.
Kuenzel, Julia
Loebrich, Markus
Jeggo, Penny A.
Downs, Jessica A.
[J]. MOLECULAR CELL, 2014, 55 (05) : 723 - 732
[43] Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression
Kasper, LH
Boussouar, F
Boyd, K
Xu, W
Biesen, M
Rehg, J
Baudino, TA
Cleveland, JL
Brindle, PK
[J]. EMBO JOURNAL, 2005, 24 (22) : 3846 - 3858
[44] HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, Brian
Johnson, Randall S.
Simon, M. Celeste
[J]. NATURE REVIEWS CANCER, 2012, 12 (01) : 9 - 22
[45] The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts
Kelly, Richard D. W.
Cowley, Shaun M.
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2013, 41 : 741 - 749
[46] SWI/SNF Regulates the Cellular Response to Hypoxia
Kenneth, Niall S.
Mudie, Sharon
van Uden, Patrick
Rocha, Sonia
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (07) : 4123 - 4131
[47] Regulation of gene expression by hypoxia
Kenneth, Niall Steven
Rocha, Sonia
[J]. BIOCHEMICAL JOURNAL, 2008, 414 : 19 - 29
[48] A transient ischemic environment induces reversible compaction of chromatin
Kirmes, Ina
Szczurek, Aleksander
Prakash, Kirti
Charapitsa, Iryna
Heiser, Christina
Musheev, Michael
Schock, Florian
Fornalczyk, Karolina
Ma, Dongyu
Birk, Udo
Cremer, Christoph
Reid, George
[J]. GENOME BIOLOGY, 2015, 16
[49] Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
Kitamuro, T
Takahashi, K
Ogawa, K
Udono-Fujimori, R
Takeda, K
Furuyama, K
Nakayama, M
Sun, JY
Fujita, H
Hida, W
Hattori, T
Shirato, K
Igarashi, K
Shibahara, S
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) : 9125 - 9133
[50] Promoter recruitment of corepressors Sin3 and Cyc8 by activator proteins of the yeast Saccharomyces cerevisiae
Kliewe, Felix
Engelhardt, Maike
Aref, Rasha
Schueller, Hans-Joachim
[J]. CURRENT GENETICS, 2017, 63 (04) : 739 - 750

← 1 2 3 4 5 6 7 8 9 10 →