Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

被引：39
作者：
Batie, Michael [1 ]
del Peso, Luis [2 ]
Rocha, Sonia [1 ]
机构：
[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L697ZB, Merseyside, England
[2] Autonomous Madrid Univ, Inst Biomed Res, Dept Biochem, Arturo Duperier 4, Madrid 28029, Spain
来源：
BIOMEDICINES | 2018年 / 6卷 / 02期
基金：
英国惠康基金;
关键词：
hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF; INDUCIBLE FACTOR-I; HIF-BINDING SITES; GENE-EXPRESSION; EPIGENETIC REGULATION; CELLULAR-RESPONSE; BREAST-CANCER; SACCHAROMYCES-CEREVISIAE; HISTONE DEMETHYLASES; DNA METHYLATION; FLIM-FRET;
D O I：
10.3390/biomedicines6020047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.
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页数：19
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