Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

被引：37
作者：
Batie, Michael [1 ]
del Peso, Luis [2 ]
Rocha, Sonia [1 ]
机构：
[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L697ZB, Merseyside, England
[2] Autonomous Madrid Univ, Inst Biomed Res, Dept Biochem, Arturo Duperier 4, Madrid 28029, Spain
来源：
BIOMEDICINES | 2018年 / 6卷 / 02期
基金：
英国惠康基金;
关键词：
hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF; INDUCIBLE FACTOR-I; HIF-BINDING SITES; GENE-EXPRESSION; EPIGENETIC REGULATION; CELLULAR-RESPONSE; BREAST-CANCER; SACCHAROMYCES-CEREVISIAE; HISTONE DEMETHYLASES; DNA METHYLATION; FLIM-FRET;
D O I：
10.3390/biomedicines6020047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.
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页数：19
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共 134 条
  • [11] REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia
    Cavadas, Miguel A. S.
    Mesnieres, Marion
    Crifo, Bianca
    Manresa, Mario C.
    Selfridge, Andrew C.
    Scholz, Carsten C.
    Cummins, Eoin P.
    Cheong, Alex
    Taylor, Cormac T.
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [12] Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    Chen, Haobin
    Yan, Yan
    Davidson, Todd L.
    Shinkai, Yoichi
    Costa, Max
    [J]. CANCER RESEARCH, 2006, 66 (18) : 9009 - 9016
  • [13] Transcriptional repression of human cad gene by hypoxia inducible factor-1α
    Chen, KF
    Lai, YY
    Sun, HS
    Tsai, SJ
    [J]. NUCLEIC ACIDS RESEARCH, 2005, 33 (16) : 5190 - 5198
  • [14] Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
    Choi, Su Mi
    Cho, Hyun-Ju
    Cho, Heesang
    Kim, Kang Ho
    Kim, Jae Bum
    Park, Hyunsung
    [J]. NUCLEIC ACIDS RESEARCH, 2008, 36 (20) : 6372 - 6385
  • [15] Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
    Choudhry, Hani
    Schoedel, Johannes
    Oikonomopoulos, Spyros
    Camps, Carme
    Grampp, Steffen
    Harris, Adrian L.
    Ratcliffe, Peter J.
    Ragoussis, Jiannis
    Mole, David R.
    [J]. EMBO REPORTS, 2014, 15 (01) : 70 - 76
  • [16] CtBPs Sense Microenvironmental Oxygen Levels to Regulate Neural Stem Cell State
    Dias, Jose M.
    Ilkhanizadeh, Shirin
    Karaca, Esra
    Duckworth, Joshua K.
    Lundin, Vanessa
    Rosenfeld, Michael G.
    Ericson, Johan
    Hermanson, Ola
    Teixeira, Ana I.
    [J]. CELL REPORTS, 2014, 8 (03): : 665 - 670
  • [17] Chromatin architecture reorganization during stem cell differentiation
    Dixon, Jesse R.
    Jung, Inkyung
    Selvaraj, Siddarth
    Shen, Yin
    Antosiewicz-Bourget, Jessica E.
    Lee, Ah Young
    Ye, Zhen
    Kim, Audrey
    Rajagopal, Nisha
    Xie, Wei
    Diao, Yarui
    Liang, Jing
    Zhao, Huimin
    Lobanenkov, Victor V.
    Ecker, Joseph R.
    Thomson, James A.
    Ren, Bing
    [J]. NATURE, 2015, 518 (7539) : 331 - 336
  • [18] Modeling gene expression using chromatin features in various cellular contexts
    Dong, Xianjun
    Greven, Melissa C.
    Kundaje, Anshul
    Djebali, Sarah
    Brown, James B.
    Cheng, Chao
    Gingeras, Thomas R.
    Gerstein, Mark
    Guigo, Roderic
    Birney, Ewan
    Weng, Zhiping
    [J]. GENOME BIOLOGY, 2012, 13 (09):
  • [19] CtBP1 Interacts with Ikaros and Modulates Pituitary Tumor Cell Survival and Response to Hypoxia
    Dorman, Katie
    Shen, Zhongyi
    Yang, Caimei
    Ezzat, Shereen
    Asa, Sylvia L.
    [J]. MOLECULAR ENDOCRINOLOGY, 2012, 26 (03) : 447 - 457
  • [20] DNA methylation pathways and their crosstalk with histone methylation
    Du, Jiamu
    Johnson, Lianna M.
    Jacobsen, Steven E.
    Patel, Dinshaw J.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (09) : 519 - 532
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