Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

被引：37
作者：
Batie, Michael [1 ]
del Peso, Luis [2 ]
Rocha, Sonia [1 ]
机构：
[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Crown St, Liverpool L697ZB, Merseyside, England
[2] Autonomous Madrid Univ, Inst Biomed Res, Dept Biochem, Arturo Duperier 4, Madrid 28029, Spain
来源：
BIOMEDICINES | 2018年 / 6卷 / 02期
基金：
英国惠康基金;
关键词：
hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF; INDUCIBLE FACTOR-I; HIF-BINDING SITES; GENE-EXPRESSION; EPIGENETIC REGULATION; CELLULAR-RESPONSE; BREAST-CANCER; SACCHAROMYCES-CEREVISIAE; HISTONE DEMETHYLASES; DNA METHYLATION; FLIM-FRET;
D O I：
10.3390/biomedicines6020047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia.
引用
收藏
页数：19
相关论文
共 134 条
  • [1] An essential role for p300/CBP in the cellular response to hypoxia
    Arany, Z
    Huang, LE
    Eckner, R
    Bhattacharya, S
    Jiang, C
    Goldberg, MA
    Bunn, HF
    Livingston, DM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) : 12969 - 12973
  • [2] KDM2 Family Members are Regulated by HIF-1 in Hypoxia
    Batie, Michael
    Druker, Jimena
    D'Ignazio, Laura
    Rocha, Sonia
    [J]. CELLS, 2017, 6 (01)
  • [3] REST repression of neuronal genes requires components of the hSWI-SNF complex
    Battaglioli, E
    Andrés, ME
    Rose, DW
    Chenoweth, JG
    Rosenfeld, MG
    Anderson, ME
    Mandel, G
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (43) : 41038 - 41045
  • [4] Epigenetic Regulation of Surfactant Protein A Gene (SP-A) Expression in Fetal Lung Reveals a Critical Role for Suv39h Methyltransferases during Development and Hypoxia
    Benlhabib, Houda
    Mendelson, Carole R.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (10) : 1949 - 1958
  • [5] Transcription factor binding predicts histone modifications in human cell lines
    Benveniste, Dan
    Sonntag, Hans-Joachim
    Sanguinetti, Guido
    Sproul, Duncan
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (37) : 13367 - 13372
  • [6] Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
    Bremm, Anja
    Moniz, Sonia
    Mader, Julia
    Rocha, Sonia
    Komander, David
    [J]. EMBO REPORTS, 2014, 15 (12) : 1268 - 1277
  • [7] hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer
    Camps, Carme
    Buffa, Francesca M.
    Colella, Stefano
    Moore, John
    Sotiriou, Christos
    Sheldon, Helen
    Harris, Adrian L.
    Gleadle, Jonathan M.
    Ragoussis, Jiannis
    [J]. CLINICAL CANCER RESEARCH, 2008, 14 (05) : 1340 - 1348
  • [8] G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis
    Casciello, Francesco
    Al-Ejeh, Fares
    Kelly, Greg
    Brennan, Donal J.
    Ngiow, Shin Foong
    Young, Arabella
    Stoll, Thomas
    Windloch, Karolina
    Hill, Michelle M.
    Smyth, Mark J.
    Gannon, Frank
    Lee, Jason S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (27) : 7077 - 7082
  • [9] The regulation of transcriptional repression in hypoxia
    Cavadas, Miguel A. S.
    Cheong, Alex
    Taylor, Cormac T.
    [J]. EXPERIMENTAL CELL RESEARCH, 2017, 356 (02) : 173 - 181
  • [10] REST is a hypoxia-responsive transcriptional repressor
    Cavadas, Miguel A. S.
    Mesnieres, Marion
    Crifo, Bianca
    Manresa, Mario C.
    Selfridge, Andrew C.
    Keogh, Ciara E.
    Fabian, Zsolt
    Scholz, Carsten C.
    Nolan, Karen A.
    Rocha, Liliane M. A.
    Tambuwala, Murtaza M.
    Brown, Stuart
    Wdowicz, Anita
    Corbett, Danielle
    Murphy, Keith J.
    Godson, Catherine
    Cummins, Eoin P.
    Taylor, Cormac T.
    Cheong, Alex
    [J]. SCIENTIFIC REPORTS, 2016, 6
12345678910