1,1-dimethylallylcoumarins potently supress both lipopolysaccharide- and interferon-γ-induced nitric oxide generation in mouse macrophage RAW 264.7 cells

被引：119
作者：
Murakami, A
Gao, GX
Omura, M
Yano, M
Ito, C
Furukawa, H
Takahashi, D
Koshimizu, K
Ohigashi, H [1 ]
机构：
[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Kyoto 6068502, Japan
[2] Kinki Univ, Fac Biol Oriented Sci & Technol, Dept Biotechnol Sci, Wakayama 6496493, Japan
[3] Fruit Tree Res Stn, Dept Citriculture, Shizuoka 4240292, Japan
[4] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(99)00578-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We investigated the suppressive effects of 16 coumarin-related compounds on both lipopolysaccharide (LPS)- and interferon (IFN)-gamma-induced nitric oxide (NO) generation in a mouse macrophage cell line, RAW 264.7. Notably, coumarins possessing prenyl unit(s) were found to be highly active, a tendency consistent with our previous study. Among the coumarins tested, 1,1-dimethylallylcoumarins showed the highest inhibitory activity. Western blotting analysis revealed that they inhibited NO generation by suppressing inducible NO synthase (iNOS) protein expression. Our ongoing studies suggest that coumarins are prominent natural compounds that attenuate excessive and prolonged NO generation at inflammatory sites. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：59 / 62
页数：4
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