Interactions of Glucose Metabolism and Chronic Heart Failure

被引：20

作者：

Clodi, M. ^{[2
]}

Resl, M. ^{[2
]}

Stelzeneder, D. ^{[2
]}

Pacini, G. ^{[3
]}

Tura, A. ^{[3
]}

Moertl, D. ^{[1
]}

Struck, J. ^{[5
]}

Morgenthaler, N. G. ^{[5
]}

Bergmann, A. ^{[5
]}

Riedl, M. ^{[2
]}

Anderwald-Stadler, M. ^{[4
]}

Luger, A. ^{[2
]}

Pacher, R. ^{[1
]}

Huelsmann, M. ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Cardiol, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Endocrinol & Metab, A-1090 Vienna, Austria

[3] CNR, Inst Biomed Engn, Metab Unit, Padua, Italy

[4] Hietzing Hosp, Med Dept Metab Dis & Nelphrol 3, Vienna, Austria

[5] BRAHMS AG, Res & Dev, Hennigsdorf, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2009年 / 117卷 / 03期

关键词：

cardiovascular incidences; metabolic features; obesity; ASSESSING INSULIN SENSITIVITY; PLASMA ADRENOMEDULLIN LEVELS; NATRIURETIC PEPTIDE; SKELETAL-MUSCLE; FIBER-TYPE; IMMUNOLUMINOMETRIC ASSAY; VASOPRESSIN PRECURSOR; HYPERTENSIVE PATIENTS; RESISTANCE; COPEPTIN;

D O I：

10.1055/s-2008-1081211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: We evaluated insulin sensitivity and beta cell function in patients with chronic heart failure (CHF), and investigated a possible correlation of these metabolic parameters with specific biomarkers of heart failure. Additionally, we investigated the effects of two angiotensin receptor blockers (ARBs), namely telmisartan and candesartan, that were administered over a 5 month treatment period, as additional therapy to standard care. Methods and Results: The study group consisted of 94 CHF patients. Insulin sensitivity (OGIS index) and insulin secretion parameters were investigated by frequently sampled oral glucose tolerance tests and consecutive mathematical modelling. In total, 94.6 % of patients had clinically overt diabetes, impaired glucose tolerance or insulin resistance at the time of enrolment HbA1c was found to correlate to NT-proBNP, MR-proADM, CT-proET-1, and MR-proANP, but not to Copeptin. NT-proBNP correlated inversely to OGIS. None of the metabolic parameters were altered significantly after candesartan or telmisartan treatment in either the patient or standard care group. Conclusion: Insulin sensitivity and insulin secretion are impaired in CHF and biomarkers of heart failure and atherosclerotic disease correlate to glucose metabolism.

引用

页码：99 / 106

页数：8

共 60 条

[1] Survival and hospitalization in heart failure patients with or without diabetes treated with β-blockers [J].

Bobbio, M ;

Ferrua, S ;

Opasich, C ;

Porcu, M ;

Lucci, D ;

Scherillo, M ;

Tavazzi, L ;

Maggioni, AP .

JOURNAL OF CARDIAC FAILURE, 2003, 9 (03) :192-202

[2] Diabetic neuropathies - A statement by the American Diabetes Association [J].

Boulton, AJM ;

Vinik, AI ;

Arezzo, JC ;

Bril, V ;

Feldman, EL ;

Freeman, R ;

Malik, RA ;

Maser, RE ;

Sosenko, JM ;

Ziegler, D .

DIABETES CARE, 2005, 28 (04) :956-962

[3] Autonomic innervation of the human cardiac conduction system: Changes from infancy to senility - An immunohistochemical and histochemical analysis [J].

Chow, LTC ;

Chow, SSM ;

Anderson, RH ;

Gosling, JA .

ANATOMICAL RECORD, 2001, 264 (02) :169-182

[4] Metabolic syndrome and prediabetes identify overlapping but not identical populations [J].

Diamantopoulos, E. J. ;

Andreadis, E. A. ;

Tsourous, G. I. ;

Ifanti, G. K. ;

Katsanou, P. M. ;

Georgiopoulos, D. X. ;

Vassilopoulos, C. V. ;

Dimitriadis, G. ;

Raptis, S. A. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2006, 114 (07) :377-383

[5] Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha [J].

Doehner, W ;

Rauchhaus, M ;

Godsland, IF ;

Egerer, K ;

Niebauer, J ;

Sharma, R ;

Cicoira, M ;

Florea, VG ;

Coats, AJS ;

Anker, SD .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 83 (01) :73-81

[6] Midregional pro-A-type natriuretic peptide measurements for diagnosis of acute destabilized heart failure in short-of-breath patients: Comparison with B-type natriuretic peptide (BNP) and amino-terminal proBNP [J].

Gegenhuber, A ;

Struck, J ;

Poelz, W ;

Pacher, R ;

Morgenthaler, NG ;

Bergmann, A ;

Haltmayer, M ;

Mueller, T .

CLINICAL CHEMISTRY, 2006, 52 (05) :827-831

[7] Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and copeptin to predict 1-year mortality in patients with acute destabilized heart failure [J].

Gegenhuber, Alfons ;

Struck, Joachim ;

Dieplinger, Benjamin ;

Poelz, Werner ;

Pacher, Richard ;

Morgenthaler, Nils G. ;

Bergmann, Andreas ;

Haltmayer, Meinhard ;

Mueller, Thomas .

JOURNAL OF CARDIAC FAILURE, 2007, 13 (01) :42-49

[8] Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure [J].

Hambrecht, R ;

Fiehn, E ;

Yu, JT ;

Niebauer, J ;

Weigl, C ;

Hilbrich, L ;

Adams, V ;

Riede, U ;

Schuler, G .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 29 (05) :1067-1073

[9] PHYSICAL-TRAINING IN PATIENTS WITH STABLE CHRONIC HEART-FAILURE - EFFECTS ON CARDIORESPIRATORY FITNESS AND ULTRASTRUCTURAL ABNORMALITIES OF LEG MUSCLES [J].

HAMBRECHT, R ;

NIEBAUER, J ;

FIEHN, E ;

KALBERER, B ;

OFFNER, B ;

HAUER, K ;

RIEDE, U ;

SCHLIERF, G ;

KUBLER, W ;

SCHULER, G .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 25 (06) :1239-1249

[10] Hyperglycemia increases vascular adrenomedullin expression [J].

Hayashi, M ;

Shimosawa, T ;

Fujita, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (02) :453-456

← 1 2 3 4 5 6 →