Soluplus Graft Copolymer: Potential Novel Carrier Polymer in Electrospinning of Nanofibrous Drug Delivery Systems for Wound Therapy

被引：55

作者：

Paaver, Urve ^{[1
]}

Tamm, Ingrid ^{[1
]}

Laidmaee, Ivo ^{[1
,2
]}

Lust, Andres ^{[1
]}

Kirsimaee, Kalle ^{[3
]}

Veski, Peep ^{[1
]}

Kogermann, Karin ^{[1
]}

Heinaemaeki, Jyrki ^{[1
]}

机构：

[1] Univ Tartu, Fac Med, Dept Pharm, EE-50411 Tartu, Estonia

[2] Univ Tartu, Fac Med, Inst Biomed & Translat Med, Immunol Grp, EE-50411 Tartu, Estonia

[3] Univ Tartu, Inst Ecol & Earth Sci, EE-50411 Tartu, Estonia

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

AMORPHOUS STATE; X-RAY; DISSOLUTION; PIROXICAM; RELEASE;

D O I：

10.1155/2014/789765

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Electrospinning is an effective method in preparing polymeric nanofibrous drug delivery systems (DDSs) for topical wound healing and skin burn therapy applications. The aim of the present study was to investigate a new synthetic graft copolymer (Soluplus) as a hydrophilic carrier polymer in electrospinning of nanofibrous DDSs. Soluplus (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PCL-PVAc-PEG)) was applied in the nonwoven nanomats loaded with piroxicam (PRX) as a poorly water-soluble drug. Raman spectroscopy, X-ray powder diffraction, differential scanning calorimetry, and scanning electron microscopy (SEM) were used in the physical characterization of nanofibrous DDSs. According to the SEM results, the drug-loaded PCL-PVAc-PEG nanofibers were circular in cross-section with an average diameter ranging from 500 nm up to 2 mu m. Electrospinning stabilized the amorphous state of PRX. In addition, consistent and sustained-release profile was achieved with the present nanofibrous DDSs at the physiologically relevant temperature and pH applicable in wound healing therapy. In conclusion, electrospinning can be used to prepare nanofibrous DDSs of PCL-PVAc-PEG graft copolymer (Soluplus) and to stabilize the amorphous state of a poorly water-soluble PRX. The use of this synthetic graft copolymer can open new options to formulate nanofibrous DDSs for wound healing.

引用

页数：7

共 40 条

[11] Characteristics and significance of the amorphous state in pharmaceutical systems [J].

Hancock, BC ;

Zograf, G .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (01) :1-12

[12]

Hardung H., 2010, DRUG DELIVERY TECH, V10, P20, DOI DOI 10.1089/TEN.2006.12.2131

[13] A review on polymer nanofibers by electrospinning and their applications in nanocomposites [J].

Huang, ZM ;

Zhang, YZ ;

Kotaki, M ;

Ramakrishna, S .

COMPOSITES SCIENCE AND TECHNOLOGY, 2003, 63 (15) :2223-2253

[14] The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions [J].

Hughey, Justin R. ;

Keen, Justin M. ;

Miller, Dave A. ;

Kolter, Karl ;

Langley, Nigel ;

McGinity, James W. .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 48 (4-5) :758-766

[15]

Hurler J., 2012, BURNS PREVENTION CAU, P39

[16]

Jayaraman K, 2004, J NANOSCI NANOTECHNO, V4, P52, DOI 10.1166/jnn.2004.078

[17]

Jinno J, 2000, J PHARM SCI-US, V89, P268, DOI 10.1002/(SICI)1520-6017(200002)89:2<268::AID-JPS14>3.0.CO

[18]

2-F

[19] X-ray powder diffractometry in combination with principal component analysis - A tool for monitoring solid state changes [J].

Kogermann, Karin ;

Veski, Peep ;

Rantanen, Jukka ;

Naelapaa, Kaisa .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 43 (04) :278-289

[20] STRUCTURE OF THE ANTI-INFLAMMATORY DRUG 4-HYDROXY-2-METHYL-N-2-PYRIDYL-2H-1-LAMBDA-6,2-BENZOTHIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE (PIROXICAM) [J].

KOJICPRODIC, B ;

RUZICTOROS, Z .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS, 1982, 38 (NOV) :2948-2951

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