Synovial sarcoma of the neck

被引:3
作者
Ochi, N
Uozumi, M
Doi, K
Tanimoto, H
Ohbayashi, C
Inagaki, H
Nibu, K
机构
[1] Kobe Univ Hosp, Dept Otolaryngol Head & Neck Surg, Kobe, Hyogo, Japan
[2] Kobe Univ Hosp, Dept Pathol, Kobe, Hyogo, Japan
[3] Nagoya City Univ, Sch Med, Dept Pathol, Nagoya, Aichi 467, Japan
来源
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2004年 / 66卷 / 01期
关键词
synovial sarcoma; reverse-transcription polymerase chain reaction; chromosomal translocation; SSX; SYT;
D O I
10.1159/000077233
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background: Synovial sarcoma is a soft tissue sarcoma rarely seen in the head and neck. Due to its rarity and morphologic variations, diagnosis is difficult in most cases. Method: A case of synovial sarcoma arising in the upper neck is presented. The detection of the specific chromosomal translocation t(X;18)(p11.2;q11.2) is also described. Result: A specific chimeric gene, the SSX-SYT fusion gene, was identified in the formalin-fixed paraffin-embedded surgical specimen using the reverse-transcription polymerase chain reaction (RT-PCR) technique. Conclusion: Synovial sarcoma contains a characteristic chromosomal translocation, which serves as a useful diagnostic tool. RT-PCR technique has enabled to detect this specific translocation not only in fresh tissues but also in archival paraffin-embedded specimens. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:42 / 45
页数:4
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