Urinary Biomarkers of Brain Diseases

被引：101

作者：

An, Manxia ^{[1
,2
]}

Gao, Youhe ^{[1
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathophysiol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China

[3] Beijing Normal Univ, Dept Biochem & Mol Biol, Beijing Key Lab Gene Engn & Biotechnol, Beijing 100875, Peoples R China

来源：

GENOMICS PROTEOMICS & BIOINFORMATICS | 2015年 / 13卷 / 06期

关键词：

POTENTIAL BIOMARKERS; ALZHEIMERS-DISEASE; METABOLITE; METABOLOMICS; PROTEOMICS; IDENTIFICATION; DISORDER; SCHIZOPHRENIA; CHILDREN; MS;

D O I：

10.1016/j.gpb.2015.08.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Biomarkers are the measurable changes associated with a physiological or pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clinical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood, there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome.

引用

页码：345 / 354

页数：10

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