Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells

被引：4

作者：

Kurylowicz, Katarzyna ^{[1
]}

Cierniak, Agnieszka ^{[2
]}

Madej, Ewelina ^{[1
]}

Skalniak, Lukasz ^{[3
]}

Wolnicka-Glubisz, Agnieszka ^{[1
]}

机构：

[1] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Biophys, Krakow, Poland

[2] Andrzej Frycz Modrzewski Krakow, Dept Med & Hlth Sci, Krakow, Poland

[3] Jagiellonian Univ, Fac Chem, Krakow, Poland

来源：

ACTA BIOCHIMICA POLONICA | 2020年 / 67卷 / 04期

关键词：

colon cancer; PhIP; resveratrol; DNA damage; apoptosis; p53; MEAT CONSUMPTION; COLORECTAL-CANCER; RISK; ACTIVATION; PHIP; CARCINOGEN; INCREASES; TOXICITY; DEATH; LIFE;

D O I：

10.18388/abp.2020_5477

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, we investigated the influence of resveratrol on PhIP treated human colon cancer cells and compared the effect to HaCaT cells considered as normal, human keratinocytes. Our results show that resveratrol decreases DNA damage induced by PhIP in both cell types, it increases the sensitivity of LoVo cells to apoptosis and has no effect on PhIP-treated HaCaT cells. We confirm that PhIP-induced apoptosis is p53 and caspase 3/7 dependent. Interestingly, normal cells such as HaCaT are more resistant to PhIP treatment.

引用

页码：605 / 611

页数：7

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