共 30 条
Chitosan-mediated facile green synthesis of size-controllable gold nanostars for effective photothermal therapy and photoacoustic imaging
被引:38
作者:
Thi Tuong Vy Phan
[1
]
Van Tu Nguyen
[2
]
Ahn, Seok-Hwan
[4
]
Oh, Junghwan
[3
,5
]
机构:
[1] Duy Tan Univ, Inst Res & Dev, Ctr Adv Chem, Danang 550000, Vietnam
[2] Pukyong Natl Univ, Interdisciplinary Program Biomed Mech & Elect Eng, Busan 48513, South Korea
[3] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol, Busan 48513, South Korea
[4] Jungwon Univ, Dept Aero Mech Engn, Chungbuk 28024, South Korea
[5] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea
关键词:
Green synthesis;
Gold nanostars;
Chitosan;
Photothermal therapy;
Photoacoustic imaging;
NANOPARTICLES;
NANOCRYSTALS;
D O I:
10.1016/j.eurpolymj.2019.06.023
中图分类号:
O63 [高分子化学(高聚物)];
学科分类号:
070305 ;
080501 ;
081704 ;
摘要:
With the large near-infrared (NIR) absorption and the high NIR photothermal effect, gold nanostar (AuNS) has potential application in the biomedical field. However, the complicated synthesis process with toxic precursors is a serious issue for its practice. Herein, we reported a novel green synthesis procedure using chitosan polymer from marine and vitamin C for the preparation of AuNS. For the first time, chitosan was used as a stabilizer, shape-directing, and size-controllable agents for the preparation of AuNS. The size of the obtained AuNS ranged from 111 to 225 nm with different lambda(max).The AuNS exhibited near-infrared absorption with the excellent bio-compatibility toward non-cancerous cell line (MG63) and cancerous cell line (MDA-MB-231). The in vitro photothermal therapy and photoacoustic imaging with assisting of obtained AuNS were also proved the high efficiency of these nanoparticles.
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页码:492 / 501
页数:10
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