Chitosan-mediated facile green synthesis of size-controllable gold nanostars for effective photothermal therapy and photoacoustic imaging

被引:38
作者
Thi Tuong Vy Phan [1 ]
Van Tu Nguyen [2 ]
Ahn, Seok-Hwan [4 ]
Oh, Junghwan [3 ,5 ]
机构
[1] Duy Tan Univ, Inst Res & Dev, Ctr Adv Chem, Danang 550000, Vietnam
[2] Pukyong Natl Univ, Interdisciplinary Program Biomed Mech & Elect Eng, Busan 48513, South Korea
[3] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol, Busan 48513, South Korea
[4] Jungwon Univ, Dept Aero Mech Engn, Chungbuk 28024, South Korea
[5] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea
关键词
Green synthesis; Gold nanostars; Chitosan; Photothermal therapy; Photoacoustic imaging; NANOPARTICLES; NANOCRYSTALS;
D O I
10.1016/j.eurpolymj.2019.06.023
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
With the large near-infrared (NIR) absorption and the high NIR photothermal effect, gold nanostar (AuNS) has potential application in the biomedical field. However, the complicated synthesis process with toxic precursors is a serious issue for its practice. Herein, we reported a novel green synthesis procedure using chitosan polymer from marine and vitamin C for the preparation of AuNS. For the first time, chitosan was used as a stabilizer, shape-directing, and size-controllable agents for the preparation of AuNS. The size of the obtained AuNS ranged from 111 to 225 nm with different lambda(max).The AuNS exhibited near-infrared absorption with the excellent bio-compatibility toward non-cancerous cell line (MG63) and cancerous cell line (MDA-MB-231). The in vitro photothermal therapy and photoacoustic imaging with assisting of obtained AuNS were also proved the high efficiency of these nanoparticles.
引用
收藏
页码:492 / 501
页数:10
相关论文
共 30 条
[1]   Heat generation in plasmonic nanostructures: Influence of morphology [J].
Baffou, G. ;
Quidant, R. ;
Girard, C. .
APPLIED PHYSICS LETTERS, 2009, 94 (15)
[2]   High-yield synthesis of multi-branched urchin-like gold nanoparticles [J].
Bakr, Osman M. ;
Wunsch, Benjamin H. ;
Stellacci, Francesco .
CHEMISTRY OF MATERIALS, 2006, 18 (14) :3297-3301
[3]   "The Good, the Bad and the Ugly" of Chitosans [J].
Bellich, Barbara ;
D'Agostino, Ilenia ;
Semeraro, Sabrina ;
Gamini, Amelia ;
Cesaro, Attilio .
MARINE DRUGS, 2016, 14 (05)
[4]   In vivo photoacoustic monitoring using 700-nm region Raman source for targeting Prussian blue nanoparticles in mouse tumor model [J].
Bui, Nhat Quang ;
Cho, Soon-Woo ;
Moorthy, Madhappan Santha ;
Park, Sang Min ;
Piao, Zhonglie ;
Nam, Seung Yun ;
Kang, Hyun Wook ;
Kim, Chang-Seok ;
Oh, Junghwan .
SCIENTIFIC REPORTS, 2018, 8
[5]   Chemistry and properties of nanocrystals of different shapes [J].
Burda, C ;
Chen, XB ;
Narayanan, R ;
El-Sayed, MA .
CHEMICAL REVIEWS, 2005, 105 (04) :1025-1102
[6]   Plasmon resonances of a gold nanostar [J].
Hao, Feng ;
Nehl, Colleen L. ;
Hafner, Jason H. ;
Nordlander, Peter .
NANO LETTERS, 2007, 7 (03) :729-732
[7]   Synthesis of polysaccharide-stabilized gold and silver nanoparticles: a green method [J].
Huang, HZ ;
Yang, XR .
CARBOHYDRATE RESEARCH, 2004, 339 (15) :2627-2631
[8]   Preparation and characterization of metal-chitosan nanocomposites [J].
Huang, HZ ;
Yuan, Q ;
Yang, XR .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2004, 39 (1-2) :31-37
[9]   Plasmonic photo-thermal therapy (PPTT) [J].
Huang, Xiaohua ;
El-Sayed, Mostafa A. .
ALEXANDRIA JOURNAL OF MEDICINE, 2011, 47 (01) :1-9
[10]   Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy [J].
Huang, Xiaohua ;
El-Sayed, Mostafa A. .
JOURNAL OF ADVANCED RESEARCH, 2010, 1 (01) :13-28