Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

被引：54

作者：

Antelmi, Elena ^{[1
,2
]}

Pizza, Fabio ^{[1
,2
]}

Donadio, Vincenzo ^{[1
,2
]}

Filardi, Marco ^{[1
]}

Sosero, Yuri L. ^{[1
]}

Incensi, Alex ^{[2
]}

Vandi, Stefano ^{[1
,2
]}

Maresco, Monica ^{[1
,2
]}

Ferri, Raffaele ^{[3
]}

Marelli, Sara ^{[4
,5
]}

Ferini-Strambi, Luigi ^{[4
,5
]}

Liguori, Rocco ^{[1
,2
]}

Plazzi, Giuseppe ^{[1
,2
]}

机构：

[1] Univ Bologna, Alma Mater Studiorum, Dept Biomed & Neuromotor Sci, Bologna, Italy

[2] IRCCS, Ist Sci Neurol Bologna, Bologna, Italy

[3] IRCCS, Oasi Res Inst, Sleep Res Ctr, Troina, Italy

[4] Univ Vita Salute San Raffaele, Milan, Italy

[5] IRCCS, San Raffaele Sci Inst, Neurol Sleep Disorders Ctr, Dept Clin Neurosci, Milan, Italy

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2019年 / 6卷 / 09期

关键词：

ALPHA-SYNUCLEIN DEPOSITS; EYE-MOVEMENT SLEEP;

D O I：

10.1002/acn3.50833

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated alpha-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated alpha-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

引用

收藏

页码：1872 / 1876

页数：5

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