The orexin system regulates alcohol-seeking in rats

被引：324
作者：
Lawrence, Andrew J. [1 ]
Cowen, Michael S.
Yang, Hong-Ju
Chen, Feng
Oldfield, Brian
机构：
[1] Univ Melbourne, Howard Florey Inst, Brain Injury & Repair Grp, Parkville, Vic 3010, Australia
[2] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia
[3] Inst Pharmacol & Toxicol, Beijing, Peoples R China
[4] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2006年 / 148卷 / 06期
关键词：
orexin; alcohol; reinstatement; drug-seeking;
D O I：
10.1038/sj.bjp.0706789
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1 Orexin-containing neurons have been implicated in feeding, sleep-wake cycles and more recently in drug-seeking behaviour. 2 Pretreatment of alcohol-preferring (iP) rats with an orexin, receptor antagonist (SB-334867, 20 mg kg(-1), intraperitoneally) completely abolished an olfactory cue-induced reinstatement of alcohol-seeking behaviour, and also attenuated alcohol responding under an operant fixed ratio regimen without affecting water responding. 3 The mRNA encoding orexin within the hypothalamus was expressed at a similar density in iP and non-preferring (NP) rats; chronic consumption of ethanol in iP rats did not significantly regulate the density of this expression, but did increase the area of expression within the lateral, but not medial, hypothalamus. 4 These data indicate that while orexin may not be implicated in the development of an alcohol preference, re-exposure of cues previously associated with alcohol availability is sufficient and adequate to activate orexin-containing neurons and drive reinstatement of alcohol-seeking.
引用
收藏
页码：752 / 759
页数：8
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