The orexin system regulates alcohol-seeking in rats

被引：324

作者：

Lawrence, Andrew J. ^{[1
]}

Cowen, Michael S.

Yang, Hong-Ju

Chen, Feng

Oldfield, Brian

机构：

[1] Univ Melbourne, Howard Florey Inst, Brain Injury & Repair Grp, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia

[3] Inst Pharmacol & Toxicol, Beijing, Peoples R China

[4] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2006年 / 148卷 / 06期

关键词：

orexin; alcohol; reinstatement; drug-seeking;

D O I：

10.1038/sj.bjp.0706789

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Orexin-containing neurons have been implicated in feeding, sleep-wake cycles and more recently in drug-seeking behaviour. 2 Pretreatment of alcohol-preferring (iP) rats with an orexin, receptor antagonist (SB-334867, 20 mg kg(-1), intraperitoneally) completely abolished an olfactory cue-induced reinstatement of alcohol-seeking behaviour, and also attenuated alcohol responding under an operant fixed ratio regimen without affecting water responding. 3 The mRNA encoding orexin within the hypothalamus was expressed at a similar density in iP and non-preferring (NP) rats; chronic consumption of ethanol in iP rats did not significantly regulate the density of this expression, but did increase the area of expression within the lateral, but not medial, hypothalamus. 4 These data indicate that while orexin may not be implicated in the development of an alcohol preference, re-exposure of cues previously associated with alcohol availability is sufficient and adequate to activate orexin-containing neurons and drive reinstatement of alcohol-seeking.

引用

页码：752 / 759

页数：8

共 57 条

[1]

[Anonymous], GLOB STAT REP ALC

[2] Overlapping distributions of orexin/hypocretin- and dopamine-β-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress [J].