Natural killer cell memory in infection, inflammation and cancer

被引：432

作者：

Cerwenka, Adelheid ^{[1
]}

Lanier, Lewis L. ^{[2
]}

机构：

[1] German Canc Res Ctr D080, Innate Immun Grp, D-69120 Heidelberg, Germany

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HUMAN CYTOMEGALOVIRUS-INFECTION; MOLONEY LEUKEMIA-CELLS; NKG2C(+) NK CELLS; MOUSE CYTOMEGALOVIRUS; CUTTING EDGE; ADAPTIVE IMMUNITY; IN-VIVO; FUNCTIONAL-HETEROGENEITY; ADOPTIVE TRANSFER; INTERFERON-GAMMA;

D O I：

10.1038/nri.2015.9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological memory can be defined as a quantitatively and qualitatively enhanced immune response upon rechallenge. For natural killer (NK) cells, two main types of memory exist. First, similarly to T cells and B cells, NK cells can exert immunological memory after encounters with stimuli such as haptens or viruses, resulting in the generation of antigen-specific memory NK cells. Second, NK cells can remember inflammatory cytokine milieus that imprint long-lasting non-antigen-specific NK cell effector function. The basic concepts derived from studying NK cell memory provide new insights about innate immunity and could lead to novel strategies to improve treatments for infectious diseases and cancer.

引用

页码：112 / 123

页数：12

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