HIGHLY CHEMOSELECTIVE SYNTHESIS OF BENZIMIDAZOLES IN SC(OTF)3-CATALYZED SYSTEM

被引：21

作者：

Fan, Liyan ^{[1
]}

Kong, Lulu ^{[1
]}

Chen, Wen ^{[1
]}

机构：

[1] Tongji Univ, Dept Chem, 1239 Siping Rd, Shanghai 200092, Peoples R China

来源：

HETEROCYCLES | 2015年 / 91卷 / 12期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; IONIC LIQUID; 2-ARYL BENZIMIDAZOLES; RECEPTOR ANTAGONISTS; EFFICIENT; CATALYST; ACID; 2-ARYLBENZIMIDAZOLES; BENZOXAZOLES; DESIGN;

D O I：

10.3987/COM-15-13326

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The present researches elicit a simple, green and efficient method for the synthesis of substituted benzimidazoles through the coupling of o-phenylenediames with aldehydes catalyzed by Sc(OTf)(3) in ethanol, which obtains high chemoselectivity and excellent yield of many biologically active 1,2-disubstitued and 2-substituted benzimidazoles respectively and are also environment friendly.

引用

页码：2306 / 2314

页数：9

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