The Response of Newly Born Mice to Odors of Murine Colostrum and Milk: Unconditionally Attractive, Conditionally Discriminated

被引:11
作者
Al Ain, Syrina [1 ]
Mingioni, Mathieu [1 ]
Patris, Bruno [1 ]
Schaal, Benoist [1 ]
机构
[1] Ctr Sci Gout, Dev Ethol & Cognit Psychol Grp, Dijon, France
关键词
Laboratory mouse (Mus musculus); newborn; olfaction; colostrum; milk; sucking; lactation; 1ST SUCKLING EPISODE; IN-HOUSE MICE; MOUSE MILK; NEWBORN; EXPOSURE; LACTATION; SUCKING; ALTERS; RATS; FAT;
D O I
10.1002/dev.21220
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
It is a general rule that milk conveys chemosensory cues that are attractive to mammalian neonates. This study investigated whether compositional fluctuations in milk along lactation induce variations in newborn mouse pups' (Mus musculus, strain BALB/c) attraction to milk odor. Pups differing in suckling experience were exposed to the odor of milk sampled from females varying in lactational stage. Immediately after birth, suckling-inexperienced (P0) and suckling-experienced (P0(suck)) pups were assayed in a series of paired-choice tests contrasting murine milk [of lactation days 0, 3, 15 (abridged L0, L3, L15, respectively)] and a blank (water) to evaluate olfactory detection and attraction of milk odor. Preference tests further paired these milk two-by-two to assess their relative attraction. Results showed first that P0 and P0(suck) pups detect and positively orient to any milk odor. When L0 is presented against L15 milk, P0 pups orient for a similar duration towards these odor stimuli, whereas P0(suck) pups spend more time toward the odor of L0 than of L15 milk. Finally, P0(suck) pups orient similarly to odors of L0 milk collected before/after the first suckling episode (L0 and L0(suck), respectively), but the odor of L0 milk was more attractive than that of L3 milk. Thus, mouse pups' positive orientation toward the odors of murine colostrum (assumed to correspond to L0/L0(suck) milk) and later-lactation milk appears unconditional of previous suckling experience, whereas their ability to discriminate or display preference between milk differing in lactation stage appears conditional on postnatal exposure effects. (c) 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1365-1376, 2014.
引用
收藏
页码:1365 / 1376
页数:12
相关论文
共 98 条
[1]   How Does a Newly Born Mouse Get to the Nipple? Odor Substrates Eliciting First Nipple Grasping and Sucking Responses [J].
Al Ain, Syrina ;
Belin, Laurine ;
Schaal, Benoist ;
Patris, Bruno .
DEVELOPMENTAL PSYCHOBIOLOGY, 2013, 55 (08) :888-901
[2]   Orientation of newborn mice to lactating females: Identifying biological substrates of semiochemical interest [J].
Al Ain, Syrina ;
Chraiti, Amal ;
Schaal, Benoist ;
Patris, Bruno .
DEVELOPMENTAL PSYCHOBIOLOGY, 2013, 55 (02) :113-124
[3]   An Odor Timer in Milk? Synchrony in the Odor of Milk Effluvium and Neonatal Chemosensation in the Mouse [J].
Al Ain, Syrina ;
Belin, Laurine ;
Patris, Bruno ;
Schaal, Benoist .
PLOS ONE, 2012, 7 (10)
[4]  
Alberts J. R., 1987, PERINATAL DEV PSYCHO, P12
[5]   The Experience of Being Born: A Natural Context for Learning to Suckle [J].
Alberts, Jeffrey R. ;
Ronca, April E. .
INTERNATIONAL JOURNAL OF PEDIATRICS, 2012, 2012
[6]   Long-lasting memory for an odor acquired at the mother's breast [J].
Allam, Maryse Delaunay-El ;
Soussignan, Robert ;
Patris, Bruno ;
Marlier, Luc ;
Schaal, Benoist .
DEVELOPMENTAL SCIENCE, 2010, 13 (06) :849-863
[7]   One-trial associative odor learning in neonatal mice [J].
Armstrong, CM ;
DeVito, LM ;
Cleland, TA .
CHEMICAL SENSES, 2006, 31 (04) :343-349
[8]   COLLECTION OF FORE AND HIND MILK FROM THE SOW AND THE CHANGES IN MILK-COMPOSITION DURING SUCKLING [J].
ATWOOD, CS ;
HARTMANN, PE .
JOURNAL OF DAIRY RESEARCH, 1992, 59 (03) :287-298
[9]   Transmission of antibodies from mother to young: Evolutionary strategies in a proteolytic environment [J].
Baintner, Karoly .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2007, 117 (3-4) :153-161
[10]  
Belin L., 2011, DEV PSYCHOBIOL, V53, P740