Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma

被引：45

作者：

Dunleavy, Kieron ^{[1
]}

Erdmann, Tabea ^{[2
,3
]}

Lenz, Georg ^{[2
,3
]}

机构：

[1] George Washington Univ, Canc Ctr, Washington, DC USA

[2] Univ Hosp Munster, Dept Med Hematol Oncol & Pneumol A, Munster, Germany

[3] Cluster Excellence EXC 1003, Cells Mot, Munster, Germany

来源：

CANCER TREATMENT REVIEWS | 2018年 / 65卷

关键词：

B-cell receptor signaling; BTK; P13K; PCNSL; DLBCL; NF-KAPPA-B; PARAFFIN-EMBEDDED TISSUE; NON-HODGKIN-LYMPHOMA; C-BETA INHIBITOR; PHASE-II; GENE-EXPRESSION; MOLECULAR SUBTYPES; R-CHOP; IBRUTINIB; KINASE;

D O I：

10.1016/j.ctrv.2018.01.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous diagnostic category with different molecular subtypes defined by distinct gene expression patterns and divergent mechanisms of oncogenic activation. Several studies have suggested an inferior survival for patients of the activated B-cell-like (ABC) versus the germinal center B-cell-like (GCB) DLBCL subtype which has led to increasing interest in investigating pharmacological inhibition of signaling pathways which contribute to lymphomagenesis and that are specifically utilized by ABC DLBCL cells. One of these signaling cascades is the B-cell receptor (BCR) pathway and several approaches in clinical trials to target this cascade have demonstrated promising therapeutic activity. This review discusses our current understanding of the role of BCR signaling in different DLBCL subtypes, including primary central nervous system lymphoma (PCNSL), a subgroup of DLBCL that is particularly dependent on BCR signaling. One specific aim of this review is to highlight novel approaches to therapeutically target BCR signaling in DLBCL. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：41 / 46

页数：6

共 70 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Whole genome expression profiling based on paraffin embedded tissue can be used to classify diffuse large B-cell lymphoma and predict clinical outcome [J].

Barrans, Sharon L. ;

Crouch, Simon ;

Care, Matthew A. ;

Worrillow, Lisa ;

Smith, Alex ;

Patmore, Russell ;

Westhead, David R. ;

Tooze, Reuben ;

Roman, Eve ;

Jack, Andrew S. .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 159 (04) :441-453

[3] Primary central nervous system lymphoma [J].

Batchelor, Tracy T. .

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2016, :379-385

[4] Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas [J].

Braggio, Esteban ;

Van Wier, Scott ;

Ojha, Juhi ;

McPhail, Ellen ;

Asmann, Yan W. ;

Egan, Jan ;

da Silva, Jackline Ayres ;

Schiff, David ;

Lopes, M. Beatriz ;

Decker, Paul A. ;

Valdez, Riccardo ;

Tibes, Raoul ;

Eckloff, Bruce ;

Witzig, Thomas E. ;

Stewart, A. Keith ;

Fonseca, Rafael ;

O'Neill, Brian Patrick .

CLINICAL CANCER RESEARCH, 2015, 21 (17) :3986-3994

[5] Mutational analysis of primary central nervous system lymphoma [J].

Bruno, Aurelie ;

Boisselier, Blandine ;

Labreche, Karim ;

Marie, Yannick ;

Polivka, Marc ;

Jouvet, Anne ;

Adam, Clovis ;

Figarella-Branger, Dominique ;

Miquel, Catherine ;

Eimer, Sandrine ;

Houillier, Caroline ;

Soussain, Carole ;

Mokhtari, Karima ;

Daveau, Romain ;

Hoang-Xuan, Khe .

ONCOTARGET, 2014, 5 (13) :5065-5075

[6] Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia [J].

Burger, J. A. ;

Tedeschi, A. ;

Barr, P. M. ;

Robak, T. ;

Owen, C. ;

Ghia, P. ;

Bairey, O. ;

Hillmen, P. ;

Bartlett, N. L. ;

Li, J. ;

Simpson, D. ;

Grosicki, S. ;

Devereux, S. ;

McCarthy, H. ;

Coutre, S. ;

Quach, H. ;

Gaidano, G. ;

Maslyak, Z. ;

Stevens, D. A. ;

Janssens, A. ;

Offner, F. ;

Mayer, J. ;

O'Dwyer, M. ;

Hellmann, A. ;

Schuh, A. ;

Siddiqi, T. ;

Polliack, A. ;

Tam, C. S. ;

Suri, D. ;

Cheng, M. ;

Clow, F. ;

Styles, L. ;

James, D. F. ;

Kipps, T. J. ;

Keating, Michael ;

Jen, Jie ;

Jindra, Pavel ;

Simkovic, Martin ;

Braester, Andrei ;

Ruchlemer, Rosa ;

Foa, Roberto ;

Semenzato, Gianpietro ;

Hawkins, Timothy ;

Atanasio, Carolina Moreno ;

Demirkan, Fatih ;

Kaynar, Leylagul ;

Pylypenko, Halyna ;

Fox, Christopher ;

Thirman, Michael ;

Campbell, Philip .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (25) :2425-2437

[7] Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia [J].

Byrd, John C. ;

Harrington, Bonnie ;

O'Brien, Susan ;

Jones, Jeffrey A. ;

Schuh, Anna ;

Devereux, Steve ;

Chaves, Jorge ;

Wierda, William G. ;

Awan, Farrukh T. ;

Brown, Jennifer R. ;

Hillmen, Peter ;

Stephens, Deborah M. ;

Ghia, Paolo ;

Barrientos, Jacqueline C. ;

Pagel, John M. ;

Woyach, Jennifer ;

Johnson, Dave ;

Huang, Jane ;

Wang, Xiaolin ;

Kaptein, Allard ;

Lannutti, Brian J. ;

Covey, Todd ;

Fardis, Maria ;

McGreivy, Jesse ;

Hamdy, Ahmed ;

Rothbaum, Wayne ;

Izumi, Raquel ;

Diacovo, Thomas G. ;

Johnson, Amy J. ;

Furman, Richard R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (04) :323-332

[8] Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia [J].

Byrd, John C. ;

Furman, Richard R. ;

Coutre, Steven E. ;

Flinn, Ian W. ;

Burger, Jan A. ;

Blum, Kristie A. ;

Grant, Barbara ;

Sharman, Jeff P. ;

Coleman, Morton ;

Wierda, William G. ;

Jones, Jeffrey A. ;

Zhao, Weiqiang ;

Heerema, Nyla A. ;

Johnson, Amy J. ;

Sukbuntherng, Juthamas ;

Chang, Betty Y. ;

Clow, Fong ;

Hedrick, Eric ;

Buggy, Joseph J. ;

James, Danelle F. ;

O'Brien, Susan .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) :32-42

[9] The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications [J].

Campo, Elias ;

Swerdlow, Steven H. ;

Harris, Nancy L. ;

Pileri, Stefano ;

Stein, Harald ;

Jaffe, Elaine S. .

BLOOD, 2011, 117 (19) :5019-5032

[10] Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma [J].

Caro, Pilar ;

Kishan, Amar U. ;

Norberg, Erik ;

Stanley, Illana A. ;

Chapuy, Bjoern ;

Ficarro, Scott B. ;

Polak, Klaudia ;

Tondera, Daniel ;

Gounarides, John ;

Yin, Hong ;

Zhou, Feng ;

Green, Michael R. ;

Chen, Linfeng ;

Monti, Stefano ;

Marto, Jarrod A. ;

Shipp, Margaret A. ;

Danial, Nika N. .

CANCER CELL, 2012, 22 (04) :547-560

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