An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones Catalyzed by Iron(III) Chloride

被引：24

作者：

Mekala, Ramamohan ^{[1
,2
]}

Akula, Raghunadh ^{[1
]}

Kamaraju, Raghavendra Rao ^{[1
]}

Bannoth, Chandrasekhar Kothapalli ^{[2
]}

Regati, Sridhar ^{[1
]}

Sarva, Jayaprakash ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Custom Pharmaceut Serv, Technol Dev Ctr, Hyderabad 500049, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Dept Chem, Anantapur 515002, Andhra Pradesh, India

来源：

SYNLETT | 2014年 / 25卷 / 06期

关键词：

heterocycles; polycycles; ketones; catalysis; iron; quinazolinones; ONE-POT SYNTHESIS; MICROWAVE IRRADIATION; DERIVATIVES; ALKALOIDS; QUINAZOLINONES; INHIBITORS; AMIDOXIMES; CHEMISTRY; DESIGN; IODINE;

D O I：

10.1055/s-0033-1340786

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and highly efficient synthesis of 2-substituted quinazolin-4(3H)-ones by the iron(III) chloride catalyzed reaction of isatoic anhydride with various amidoxime derivatives was developed. Several aryl and alkyl amidoximes were screened to demonstrate the scope of the methodology.

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收藏

页码：821 / 826

页数：6

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