Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp.

被引：18
作者：
Wei, Chengwen [1 ]
Deng, Qin [2 ]
Sun, Mengyu [1 ]
Xu, Jing [1 ,2 ]
机构：
[1] Hainan Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Adv Mat Trop Isl Resources, Haikou 570228, Hainan, Peoples R China
[2] Hainan Univ, Coll Hort & Landscape, Haikou 570228, Hainan, Peoples R China
来源：
MOLECULES | 2020年 / 25卷 / 18期
基金：
中国国家自然科学基金;
关键词：
Cytospora sp; polyketides; structure identification; antimicrobial activity; cytotoxicity; ANTIBIOTICS; INTEGRACINS;
D O I：
10.3390/molecules25184224
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new polyketides, cytospyrone (1), cytospomarin (2), together with three known metabolites dimethoxyphtalide (3), integracin A (4) and integracin B (5), were isolated from the culture of Cytospora sp. from the Chinese mangrove Ceriops tagal. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound 2 displayed weak inhibitory activity against Escherichia coli GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds 4 and 5 displayed significant cytotoxicity against human cancer cell line HepG2 (IC50 values of 5.98 +/- 0.12 mu M and 9.97 +/- 0.06 mu M, respectively), more potent than the positive control 5-fluorouracil (IC50 value of 43.50 +/- 3.69 mu M).
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页数：9
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