Sex, gut microbiome, and cardiovascular disease risk

被引:106
作者
Razavi, Alexander C. [1 ,2 ]
Potts, Kaitlin S. [2 ]
Kelly, Tanika N. [2 ]
Bazzano, Lydia A. [1 ,2 ]
机构
[1] Tulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St,Suite 2000, New Orleans, LA 70112 USA
关键词
Gut microbiome; Cardiovascular diseases; Sex difference; Obesity; Lipids; Insulin; Blood pressure; TMAO; CHAIN FATTY-ACIDS; TRIMETHYLAMINE-N-OXIDE; FARNESOID-X-RECEPTOR; BLOOD-PRESSURE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; INTESTINAL MICROBIOTA; GENDER-DIFFERENCES; BILE-ACID; ARTERIAL-HYPERTENSION;
D O I
10.1186/s13293-019-0240-z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular disease and associated metabolic conditions; therefore, gut microbiota may be key mediators or modulators driving the observed sexual dimorphism in disease onset and progression. While current evidence regarding pure physiological sex differences in gut microbiome composition is modest, robust research suggests that gut microbiome-dependent metabolites may interact with important biological pathways under sex hormone control, including toll-like receptor and flavin monooxygenase signaling. Here, we review key sex differences in gut microbiome interactions with four primary determinants of cardiovascular disease, impaired glucose regulation, dyslipidemia, hypertension, and obesity. Through this process, we propose important sex differences in downstream metabolic pathways that may be at the interface of the gut microbiome and cardiovascular disease.
引用
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页数:14
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