Ventilator-Associated Pneumonia in Neonatal Patients: An Update

被引:91
作者
Cernada, Maria [1 ,2 ]
Brugada, Maria [1 ,2 ]
Golombek, Sergio [3 ]
Vento, Maximo [1 ,2 ]
机构
[1] Univ & Polytech Hosp La Fe, Hlth Res Inst La Fe, Neonatal Res Unit, ES-46026 Valencia, Spain
[2] Univ & Polytech Hosp La Fe, Div Neonatol, ES-46026 Valencia, Spain
[3] New York Med Coll, Westchester Med Ctr, Maria Fareri Childrens Hosp, Reg Neonatal Ctr, Valhalla, NY 10595 USA
关键词
Newborn; Mechanical ventilation; Infections; Pneumonia; Intubation; INTENSIVE-CARE-UNIT; NOSOCOMIAL INFECTIONS; RISK-FACTORS; BRONCHOALVEOLAR LAVAGE; SERUM PROCALCITONIN; ANTIBIOTIC-THERAPY; PREVENTION; STRATEGIES; BIOMARKERS; DIAGNOSIS;
D O I
10.1159/000355539
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Ventilator-associated pneumonia (VAP) is a serious complication related to mechanical ventilation in the neonatal period. However, lack of a specific definition and difficulties obtaining noncontaminated samples of the lower respiratory airway render microbiological diagnosis and etiological treatment extremely difficult. Thus far, only few studies have approached VAP using accepted Centers for Disease Control and Prevention criteria and reliable sampling techniques. In recent years, however, the blind-protected bronchoalveolar lavage technique with protected specimen brush and the development of validated biomarkers have attempted to overcome the diagnostic difficulties and assess the response to therapy. This updated review on neonatal VAP aims to stimulate neonatologists' interest in this subtle but serious complication of mechanical ventilation. (C) 2013 S. Karger AG, Basel
引用
收藏
页码:98 / 107
页数:10
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