Introduction: There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently available for the treatment of the inflammatory phase of this disabling disease; however, the need for treating neurodegeneration and halting the progression of disability is still unmet.Areas covered: In this paper we review the available information on existing and emerging DMTs and we discuss their place within the context of different treatment strategies in MS,Expert commentary: The future of MS treatments should include the development of new treatment strategies tackling disease progression, together with a better understanding of the side-effects and the best sequential strategy of implementation of available and emerging drugs.
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Univ London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, EnglandUniv London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
Ali, Rehiana
Nicholas, Richard St John
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Imperial Coll Healthcare NHS Trust, London, EnglandUniv London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
Nicholas, Richard St John
Muraro, Paolo Antonio
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Univ London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
Imperial Coll Healthcare NHS Trust, London, EnglandUniv London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Atkins, Harold L.
Bowman, Marjorie
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Ottawa Hosp, MS Clin, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bowman, Marjorie
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Allan, David
Anstee, Grizel
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Anstee, Grizel
Arnold, Douglas L.
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada
NeuroRx Res, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Arnold, Douglas L.
Bar-Or, Amit
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada
McGill Univ, Montreal Neurol Inst & Hosp, Neuroimmunol Unit, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bar-Or, Amit
Bence-Bruckler, Isabelle
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bence-Bruckler, Isabelle
Birch, Paul
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Canadian Blood Serv, Ottawa Stem Cell Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Birch, Paul
Bredeson, Christopher
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bredeson, Christopher
Chen, Jacqueline
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada
Cleveland Clin, Dept Neurosci, Cleveland, OH 44106 USAOttawa Hosp, Res Inst, Ottawa, ON, Canada
Chen, Jacqueline
Fergusson, Dean
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Fergusson, Dean
Halpenny, Mike
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Canadian Blood Serv, Ottawa Stem Cell Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Halpenny, Mike
Hamelin, Linda
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Hamelin, Linda
Huebsch, Lothar
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Huebsch, Lothar
Hutton, Brian
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Ottawa Hosp, Res Inst, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Hutton, Brian
Laneuville, Pierre
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McGill Univ, Ctr Hlth, Montreal, PQ, Canada
McGill Univ, Div Oncol, Dept Med, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Laneuville, Pierre
Lapierre, Yves
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Lapierre, Yves
Lee, Hyunwoo
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Lee, Hyunwoo
Martin, Lisa
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Canadian Blood Serv, Ottawa Stem Cell Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Martin, Lisa
McDiarmid, Sheryl
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
McDiarmid, Sheryl
O'Connor, Paul
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Univ Toronto, St Michaels Hosp, Div Neurol, Toronto, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
O'Connor, Paul
Ramsay, Timothy
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h-index: 0
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Ramsay, Timothy
Sabloff, Mitchell
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Sabloff, Mitchell
Walker, Lisa
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Univ Ottawa, Sch Psychol, Ottawa, ON, Canada
Ottawa Hosp, MS Clin, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Walker, Lisa
Freedman, Mark S.
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, Canada
Ottawa Hosp, MS Clin, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
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Univ London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, EnglandUniv London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
Ali, Rehiana
Nicholas, Richard St John
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h-index: 0
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Imperial Coll Healthcare NHS Trust, London, EnglandUniv London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
Nicholas, Richard St John
Muraro, Paolo Antonio
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h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
Imperial Coll Healthcare NHS Trust, London, EnglandUniv London Imperial Coll Sci Technol & Med, Div Brain Sci, London W12 0NN, England
机构:
Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Atkins, Harold L.
Bowman, Marjorie
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h-index: 0
机构:
Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Ottawa Hosp, MS Clin, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bowman, Marjorie
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Allan, David
Anstee, Grizel
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h-index: 0
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Anstee, Grizel
Arnold, Douglas L.
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h-index: 0
机构:
McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada
NeuroRx Res, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Arnold, Douglas L.
Bar-Or, Amit
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h-index: 0
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada
McGill Univ, Montreal Neurol Inst & Hosp, Neuroimmunol Unit, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bar-Or, Amit
Bence-Bruckler, Isabelle
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bence-Bruckler, Isabelle
Birch, Paul
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h-index: 0
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Canadian Blood Serv, Ottawa Stem Cell Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Birch, Paul
Bredeson, Christopher
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Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Bredeson, Christopher
Chen, Jacqueline
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h-index: 0
机构:
McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada
Cleveland Clin, Dept Neurosci, Cleveland, OH 44106 USAOttawa Hosp, Res Inst, Ottawa, ON, Canada
Chen, Jacqueline
Fergusson, Dean
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h-index: 0
机构:
Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Fergusson, Dean
Halpenny, Mike
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h-index: 0
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Canadian Blood Serv, Ottawa Stem Cell Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Halpenny, Mike
Hamelin, Linda
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h-index: 0
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Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Hamelin, Linda
Huebsch, Lothar
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h-index: 0
机构:
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Huebsch, Lothar
Hutton, Brian
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h-index: 0
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Ottawa Hosp, Res Inst, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Hutton, Brian
Laneuville, Pierre
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h-index: 0
机构:
McGill Univ, Ctr Hlth, Montreal, PQ, Canada
McGill Univ, Div Oncol, Dept Med, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Laneuville, Pierre
Lapierre, Yves
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h-index: 0
机构:
McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Lapierre, Yves
Lee, Hyunwoo
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h-index: 0
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McGill Univ, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Lee, Hyunwoo
Martin, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Canadian Blood Serv, Ottawa Stem Cell Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Martin, Lisa
McDiarmid, Sheryl
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h-index: 0
机构:
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
McDiarmid, Sheryl
O'Connor, Paul
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h-index: 0
机构:
Univ Toronto, St Michaels Hosp, Div Neurol, Toronto, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
O'Connor, Paul
Ramsay, Timothy
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h-index: 0
机构:
Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Ramsay, Timothy
Sabloff, Mitchell
论文数: 0引用数: 0
h-index: 0
机构:
Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Sabloff, Mitchell
Walker, Lisa
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h-index: 0
机构:
Univ Ottawa, Sch Psychol, Ottawa, ON, Canada
Ottawa Hosp, MS Clin, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada
Walker, Lisa
Freedman, Mark S.
论文数: 0引用数: 0
h-index: 0
机构:
Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Univ Ottawa, Dept Med, Ottawa, ON, Canada
Ottawa Hosp, MS Clin, Ottawa, ON, CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada