Loss of 14q chromosome in oligodendroglial and astrocytic tumors

被引：18
作者：
Dichamp, C
Taillibert, S
Aguirre-Cruz, L
Lejeune, J
Marie, Y
Kujas, ME
Delattre, JY
Hoang-Xuan, K
Sanson, M
机构：
[1] Univ Paris 06, Hop La Pitie Salpetriere, Federat Neurol Mazarin, F-75013 Paris, France
[2] Univ Paris 06, Hop La Pitie Salpetriere, INSERM, U495, F-75013 Paris, France
[3] Univ Paris 06, Hop La Pitie Salpetriere, Lab Neuropathol R Escourolle, U495, F-75013 Paris, France
[4] Inst Nacl Neurol & Neurocirug, Mexico City, DF, Mexico
来源：
JOURNAL OF NEURO-ONCOLOGY | 2004年 / 67卷 / 03期
关键词：
chromosome; 14q; glioma; oligodendroglioma; glioblastoma;
D O I：
10.1023/B:NEON.0000024218.68120.8d
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Loss of chromosome 14q has been investigated in 142 gliomas. Loss of heterozygosity (LOH) at one or more microsatellite has been found in 8/30 grade II (27%) and 2/21 grade III (10%) oligodendrogliomas, 3/9 grade II (33%) and 5/15 grade III (33%) oligoastrocytomas, 0/9 grade II (0%) and 1/7 grade III (14%) astrocytomas, 11/51 glioblastomas (22%). Two minimal regions were identified on 14q21.2 - 14q24.3 ( between D14S288 and D14S74) and 14q31.3 - 14q32.1 (between D14S74 and D14S65). Loss of 14q was not correlated to survival, histological grading and subtype or other genetic alterations, except for 1p deletions. Taken together, these data suggest that LOH14q is an early alteration involving 20% of glioma.
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页码：281 / 285
页数：5
相关论文
共 21 条
[1]   Cumulative dosage effect of a RAD51L1/HMGA2 fusion and RAD51L1 loss in a case of Pseudo-Meigs' syndrome [J].
Amant, F ;
Debiec-Rychter, M ;
Schoenmakers, EFPM ;
Hagemeijer-Hausman, A ;
Vergote, I .
GENES CHROMOSOMES & CANCER, 2001, 32 (04) :324-329
[2]  
Bandera CA, 1997, CANCER RES, V57, P513
[3]  
CHANG WYH, 1995, CANCER RES, V55, P3246
[4]   ASSOCIATION OF P53 MUTATIONS WITH SHORT SURVIVAL IN COLORECTAL-CANCER [J].
HAMELIN, R ;
LAURENTPUIG, P ;
OLSCHWANG, S ;
JEGO, N ;
ASSELAIN, B ;
REMVIKOS, Y ;
GIRODET, J ;
SALMON, RJ ;
THOMAS, G .
GASTROENTEROLOGY, 1994, 106 (01) :42-48
[5]   High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours [J].
Hu, J ;
Pang, JCS ;
Tong, CYK ;
Lau, B ;
Yin, XI ;
Poon, WS ;
Jiang, CC ;
Zhou, LF ;
Ng, HK .
BRITISH JOURNAL OF CANCER, 2002, 87 (02) :218-224
[6]   RELIABILITY OF DIFFERENTIAL PCR FOR THE DETECTION OF EGFR AND MDM2 GENE AMPLIFICATION IN DNA EXTRACTED FROM FFPE GLIOMA TISSUE [J].
HUNTER, SB ;
ABBOTT, K ;
VARMA, VA ;
OLSON, JJ ;
BARNETT, DW ;
JAMES, CD .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1995, 54 (01) :57-64
[7]  
Kros JM, 1999, J PATHOL, V188, P282
[8]  
Lee DJ, 1997, CLIN CANCER RES, V3, P501
[9]   Glioma classification - A molecular reappraisal [J].
Louis, DN ;
Holland, EC ;
Cairncross, JG .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (03) :779-786
[10]   Frequent loss of chromosome 14 in atypical and malignant meningioma: Identification of a putative 'tumor progression' locus [J].
Menon, AG ;
Rutter, JL ;
vonSattel, JP ;
Synder, H ;
Murdoch, C ;
Blumenfeld, A ;
Martuza, RL ;
vonDeimling, A ;
Gusella, JF ;
Houseal, TW .
ONCOGENE, 1997, 14 (05) :611-616
123