Four new sesquiterpene lactones from the stem bark of Illicium burmanicum

被引：5

作者：

Huang, Doudou ^{[1
]}

Deng, Huaping ^{[1
]}

Chen, Wansheng ^{[2
]}

Huang, Guanghui ^{[1
]}

Chen, Cheng ^{[1
]}

Sun, Lianna ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Dept Pharm, Changzheng Hosp, Shanghai 200003, Peoples R China

来源：

FITOTERAPIA | 2014年 / 92卷

关键词：

Illicium burmanicum; Sesquiterpene lactones; NF-kappa B; PRENYLATED C-6-C-3 COMPOUNDS; SECO-PREZIZAANE; PHENYLPROPANOIDS; GLYCOSIDES; NEOLIGNAN;

D O I：

10.1016/j.fitote.2013.11.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new sesquiterpene lactones (1), (2), (3), and (4), along with three known sesquiterene, namely, 6,7,10-trihydoxyisodaucane (5), 4 beta, 10 beta-dihydroxyaromadendrane (6), and sescrassidiol (7) were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined using 1D and 2D NMR, and HRESIMS. The anti-inflammatory activities of these compounds were evaluated by measuring the enzymatic activity of luciferase in NF-kappa B reporters in a (Luc)-HEK 293 cell line treated with lipopolysaccharide (LPS). (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：194 / 199

页数：6

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