Solitary PSMA-Positive Pulmonary Metastasis in Biochemical Relapse of Prostate Cancer

被引:10
作者
Hokamp, Nils Grosse [1 ,2 ]
Kobe, Carsten [3 ]
Linzenich, Eric [4 ]
Maintz, David [1 ,2 ]
Drzezga, Alexander [2 ,3 ]
机构
[1] Univ Hosp Cologne, Dept Diagnost & Intervent Radiol, Bergisch Gladbach, Germany
[2] Univ Hosp Cologne, Ctr Integrated Oncol, Bergisch Gladbach, Germany
[3] Univ Hosp Cologne, Dept Nucl Med, Cologne, Germany
[4] Urol Ctr Refrath, Bergisch Gladbach, Germany
关键词
prostate cancer; pulmonary metastasis; prostate-specific membrane-antigen positron emission tomography; PSA recurrence; LUNG-CANCER; NODULES; THERAPY; CT;
D O I
10.1097/RLU.0000000000001582
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A 63-year-old man with a history of prostate cancer, treated with resection, radiation, and androgen-depriving therapy over 4 years, was referred to our department with suspicion of recurrence based on increased blood PSA levels (1.60 ng/mL). Ga-68 PSMA PET/CT identified a solitary, PSMA-positive pulmonary nodule in the right lung. After resection, histologic analysis confirmed prostatic origin, and the blood PSA level decreased to 0.13 ng/mL. Solitary pulmonary metastasis from prostate cancer is rare. The benefits of local treatment of a single metastasis even in advanced disease are disputed among oncologists. Here, biochemical response to resection was excellent.
引用
收藏
页码:406 / 407
页数:2
相关论文
共 10 条
[1]   Prostate specific membrane antigen (PSMA) ligands for diagnosis and therapy of prostate cancer [J].
Barrio, Martin ;
Fendler, Wolfgang P. ;
Czernin, Johannes ;
Herrmann, Ken .
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2016, 16 (11) :1177-1188
[2]   CT-guided biopsy of pulmonary nodules: is pulmonary hemorrhage a complication or an advantage? [J].
De Filippo, Massimo ;
Saba, Luca ;
Silva, Mario ;
Zagaria, Raffaella ;
Concari, Giorgio ;
Nizzoli, Rita ;
Bozzetti, Cecilia ;
Tiseo, Marcello ;
Ardizzoni, Andrea ;
Lipia, Stefano ;
Paladini, Ilaria ;
Macarini, Luca ;
Carrafiello, Giampaolo ;
Brunese, Luca ;
Rotondo, Antonio ;
Rossi, Cristina .
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, 2014, 20 (05) :421-425
[3]   Detecting Pulmonary Nodules in Lung Cancer Patients Using Whole Body FDG PET/CT, High-resolution Lung Reformat of FDG PET/CT, or Diagnostic Breath Hold Chest CT [J].
Flavell, Robert R. ;
Behr, Spencer C. ;
Mabray, Marc C. ;
Hernandez-Pampaloni, Miguel ;
Naeger, David M. .
ACADEMIC RADIOLOGY, 2016, 23 (09) :1123-1129
[4]  
Kane DB, 2016, UROL ANN, V8, P255
[5]   The role of 18F-FDG PET or 18F-FDG-PET/CT in the evaluation of solitary pulmonary nodules [J].
Li, Wenbo ;
Pang, Hua ;
Liu, Qiong ;
Zhou, Jing .
EUROPEAN JOURNAL OF RADIOLOGY, 2015, 84 (10) :2032-2037
[6]   Metastasis-directed Therapy of Regional and Distant Recurrences After Curative Treatment of Prostate Cancer: A Systematic Review of the Literature [J].
Ost, Piet ;
Bossi, Alberto ;
Decaestecker, Karel ;
De Meerleer, Gert ;
Giannarini, Gianluca ;
Karnes, R. Jeffrey ;
Roach, Mack, III ;
Briganti, Alberto .
EUROPEAN UROLOGY, 2015, 67 (05) :852-863
[7]   Elevated 68Ga Prostate-Specific Membrane Antigen Activity in Metastatic Non-Small Cell Lung Cancer [J].
Shetty, Deepa ;
Loh, Han ;
Bui, Chuong ;
Mansberg, Robert ;
Stevanovic, Amanda .
CLINICAL NUCLEAR MEDICINE, 2016, 41 (05) :414-416
[8]   Expression of Prostate-Specific Membrane Antigen in Lung Cancer Cells and Tumor Neovasculature Endothelial Cells and Its Clinical Significance [J].
Wang, Hai-long ;
Wang, Shao-shan ;
Song, Wen-hui ;
Pan, Yi ;
Yu, Hai-peng ;
Si, Tong-guo ;
Liu, Yong ;
Cui, Xiao-nan ;
Guo, Zhi .
PLOS ONE, 2015, 10 (05)
[9]   Oligometastases revisited [J].
Weichselbaum, Ralph R. ;
Hellman, Samuel .
NATURE REVIEWS CLINICAL ONCOLOGY, 2011, 8 (06) :378-382
[10]   Prostate-specific membrane antigen expression in tumor-associated vasculature of breast cancers [J].
Wernicke, Alla Gabriella ;
Varma, Sonal ;
Greenwood, Eleni A. ;
Christos, Paul J. ;
Chao, K. S. Clifford ;
Liu, He ;
Bander, Neil H. ;
Shin, Sandra J. .
APMIS, 2014, 122 (06) :482-489