Synthesis, antimicrobial activity and QSAR studies of new 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazoles

被引：43

作者：

Minu, Maninder ^{[1
]}

Thangadurai, Ananda ^{[1
]}

Wakode, Sharad Ramesh ^{[1
]}

Agrawal, Shyam Sundar ^{[1
]}

Narasimhan, Balasubramanian ^{[2
]}

机构：

[1] Delhi Inst Pharmaceut Sci & Res, New Delhi 110017, India

[2] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 11期

关键词：

Hexahydroindazoles; Antibacterial; Antifungal; QSAR; ANTIINFLAMMATORY AGENTS; ANTIBACTERIAL AGENTS; ANTIFUNGAL ACTIVITY; ACID-DERIVATIVES; HANSCH ANALYSIS; PREDICTION; PYRAZOLINES; INDEXES; MLR;

D O I：

10.1016/j.bmcl.2009.04.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antimicrobial activity of synthesized 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives indicated that 3-(4-chlorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a, 4,5,6,7-hexahydro-2H-indazole (6) and 3-(4-fluorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a, 4,5,6,7-hexahydro-2H-indazole (20) were the most active compounds. Further, the results of QSAR studies indicated the importance of topological parameters (2)chi and (2)chi(v) in defining the antimicrobial activity of hexahydroindazoles. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2960 / 2964

页数：5

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