Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

被引：65

作者：

Agnello, Luisa ^{[1
]}

Bivona, Giulia ^{[1
]}

Vidali, Matteo ^{[3
]}

Scazzone, Concetta ^{[1
]}

Giglio, Rosaria Vincenza ^{[1
]}

Iacolino, Giorgia ^{[1
]}

Iacona, Alessandro ^{[1
]}

Mancuso, Silvia ^{[1
]}

Ciaccio, Anna Maria ^{[4
]}

Lo Sasso, Bruna ^{[1
,2
]}

Ciaccio, Marcello ^{[1
,2
]}

机构：

[1] Univ Palermo, Inst Clin Biochem Clin Mol Med & Lab Med, Dept Biomed Neurosci & Adv Diagnost, Via Vespro 129,CAP 90127, Palermo, Sicily, Italy

[2] AOUP P Giaccone, Dept Lab Med, Palermo, Italy

[3] Maggiore Carita Hosp, Unit Clin Chem, Novara, Italy

[4] Univ Palermo, Palermo, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2020年 / 58卷 / 11期

关键词：

Emergency Department (ED); infection; monocytes; monocyte distribution width (MDW); screening; sepsis; INFLAMMATORY RESPONSE SYNDROME; COMMUNITY-ACQUIRED PNEUMONIA; C-REACTIVE PROTEIN; PROCALCITONIN; NEUTROPHILS; MANAGEMENT; MORTALITY; VOLUME;

D O I：

10.1515/cclm-2020-0417

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: The diagnosis of sepsis in the Emergency Department (ED) is challenging and a reliable biomarker is needed. The current study aimed to evaluate the diagnostic accuracy of monocyte distribution width (MDW) for the early identification of sepsis in the ED. Methods: We performed a large observational study including consecutive adult patients (>= 18 years of age) presenting to the ED between September and November 2019, with an order for complete blood count (CBC) evaluation. A total of 2,215 patients were enrolled and classified based on Sepsis-2 criteria as the control group (1,855), infection group (172), Systemic Inflammatory Response Syndrome (SIRS) group (100), and sepsis group (88). Results: MDW levels were higher in patients with sepsis than in all other groups (p<0.001). ROC curve analysis showed an optimal diagnostic accuracy of MDW for sepsis prediction at a cut-off point of 23.5, with an AUC of 0.964, sensitivity and specificity of 0.920 and 0.929, respectively. Conclusions: Our findings encourage further investigation to validate the use of MDW as a screening tool for the early identification of patients at risk of sepsis in the ED.

引用

页码：1951 / 1957

页数：7

共 31 条

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