Treatment of early rheumatoid arthritis in developing countries. Biologics or disease-modifying anti-rheumatic drugs?

被引:14
作者
Yen, J. -H. [1 ]
机构
[1] Kaohsiung Med Univ Hosp, Coll Med, Grad Inst Med, Dept Internal Med,Div Rheumatol, Kaohsiung 807, Taiwan
关键词
rheumatoid arthritis; treatment; anti-rheumatic drugs;
D O I
10.1016/j.biopha.2006.09.008
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Biologics are highly effective in the treatment of rheumatoid arthritis (RA), but they are very expensive. The costs of biologics should limit their usage in patients with RA, especially in the developing countries. Therefore, it is necessary to develop suitable strategies for treating RA patients in these countries. In this article, the efficacy, toxicity, and cost-effectiveness of conventional DMARDs and biologics will be investigated. The therapeutic strategies for treating early RA will also be proposed. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:688 / 692
页数:5
相关论文
共 51 条
  • [1] [Anonymous], COCHRANE DATABASE SY
  • [2] A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    Bathon, JM
    Martin, RW
    Fleischmann, RM
    Tesser, JR
    Schiff, MH
    Keystone, EC
    Genovese, MC
    Wasko, MC
    Moreland, LW
    Weaver, AL
    Markenson, J
    Finck, BK
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (22) : 1586 - 1593
  • [3] Baumgartner SW, 2004, J RHEUMATOL, V31, P1532
  • [4] BLUMENAUER B, 2002, COCHRANE DB SYST REV, V4, P3785
  • [5] Add-on or step-up trials for new drug development in rheumatoid arthritis: A new standard?
    Boers, M
    [J]. ARTHRITIS AND RHEUMATISM, 2003, 48 (06): : 1481 - 1483
  • [6] Infliximab in active early rheumatoid arthritis
    Breedveld, FC
    Emery, P
    Keystone, E
    Patel, K
    Furst, DE
    Kalden, JR
    St Clair, EW
    Weisman, M
    Smolen, J
    Lipsky, PE
    Maini, RN
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 (02) : 149 - 155
  • [7] The PREMIER study - A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    Breedveld, FC
    Weisman, MH
    Kavanaugh, AF
    Cohen, SB
    Pavelka, K
    van Vollenhoven, R
    Sharp, J
    Perez, JL
    Spencer-Green, GT
    [J]. ARTHRITIS AND RHEUMATISM, 2006, 54 (01): : 26 - 37
  • [8] Clinical and radiological effects of anakinra in patients with rheumatoid arthritis
    Bresnihan, B
    Cobby, M
    [J]. RHEUMATOLOGY, 2003, 42 : 22 - 28
  • [9] Çalgüneri M, 1999, CLIN EXP RHEUMATOL, V17, P699
  • [10] Choi HK, 2000, ARTHRITIS RHEUM, V43, P2316, DOI 10.1002/1529-0131(200010)43:10<2316::AID-ANR20>3.0.CO