DNA Methylation in Major Depressive Disorder

被引：29

作者：

Pishva, Ehsan ^{[1
,2
]}

Rutten, Bart P. F. ^{[2
]}

van den Hove, Daniel ^{[2
,3
]}

机构：

[1] Univ Exeter, Sch Med, Complex Dis Epigenet Grp, RD&E Hosp Wonford, RILD Bldg,Barrack Rd, Exeter EX2 5DW, Devon, England

[2] Maastricht Univ, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci MHeNS, Univ Singel 50, NL-6200 MD Maastricht, Netherlands

[3] Univ Wurzburg, Lab Translat Neurosci, Dept Psychiat Psychosomat & Psychotherapy, Fuechsleinstr 15, D-97080 Wurzburg, Germany

来源：

NEUROEPIGENOMICS IN AGING AND DISEASE | 2017年 / 978卷

关键词：

Epigenetics; DNA methylation; Major depressive diorders; Antidepressants; BDNF PROMOTER METHYLATION; SEROTONIN TRANSPORTER GENE; ANTIDEPRESSANT TREATMENT; NEUROTROPHIC FACTOR; ENVIRONMENT INTERACTIONS; SLC6A4; METHYLATION; STRESS; ASSOCIATION; PATHOPHYSIOLOGY; EXPOSURE;

D O I：

10.1007/978-3-319-53889-1_10

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetic mechanisms regulate gene expression, influencing protein levels and ultimately shaping phenotypes during life. However, both stochastic epigenetic variations and environmental reprogramming of the epigenome might influence neurodevelopment and ageing, and this may contribute to the origins of mental ill-health. Studying the role of epigenetic mechanisms is challenging, as genotype-, tissue-and cell type-dependent epigenetic changes have to be taken into account, while the nature of mental disorders also poses significant challenges for linking them with biological profiles. In this chapter, we summarise the current evidence suggesting the role of DNA methylation as a key epigenetic mechanism in major depressive disorder.

引用

收藏

页码：185 / 196

页数：12

相关论文

共 51 条

[1]

Binder EB, 2009, PSYCHONEUROENDOCRINO, V34, P99, DOI [10.1016/j.psyneuen.2008.08.018, 10.1016/j.psyneuen.2009.05.021]

[2] DNA Methylation of the Serotonin Transporter Gene in Peripheral Cells and Stress-Related Changes in Hippocampal Volume: A Study in Depressed Patients and Healthy Controls [J].

Booij, Linda ;

Szyf, Moshe ;

Carballedo, Angela ;

Frey, Eva-Maria ;

Morris, Derek ;

Dymov, Sergiy ;

Vaisheva, Farida ;

Ly, Victoria ;

Fahey, Ciara ;

Meaney, James ;

Gill, Michael ;

Frodl, Thomas .

PLOS ONE, 2015, 10 (03)

[3] Epigenetic regulation of the BDNF gene: implications for psychiatric disorders [J].

Boulle, F. ;

van den Hove, D. L. A. ;

Jakob, S. B. ;

Rutten, B. P. ;

Hamon, M. ;

van Os, J. ;

Lesch, K-P ;

Lanfumey, L. ;

Steinbusch, H. W. ;

Kenis, G. .

MOLECULAR PSYCHIATRY, 2012, 17 (06) :584-596

[4] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[5] Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression [J].

Choi, Sunyoung ;

Han, Kyu-Man ;

Won, Eunsoo ;

Yoon, Bong-June ;

Lee, Min-Soo ;

Ham, Byung-Joo .

JOURNAL OF AFFECTIVE DISORDERS, 2015, 172 :74-80

[6] Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins [J].

Cordova-Palomera, A. ;

Fatjo-Vilas, M. ;

Gasto, C. ;

Navarro, V. ;

Krebs, M-O ;

Fananas, L. .

TRANSLATIONAL PSYCHIATRY, 2015, 5 :e557-e557

[7] Serotonin Transporter Gene Methylation is Associated With Hippocampal Gray Matter Volume [J].

Dannlowski, Udo ;

Kugel, Harald ;

Redlich, Ronny ;

Halik, Adriane ;

Schneider, Ilona ;

Opel, Nils ;

Grotegerd, Dominik ;

Schwarte, Kathrin ;

Schettler, Christiane ;

Ambree, Oliver ;

Rust, Stephan ;

Domschke, Katharina ;

Arolt, Volker ;

Heindel, Walter ;

Baune, Bernhard T. ;

Suslow, Thomas ;

Zhang, Weiqi ;

Hohoff, Christa .

HUMAN BRAIN MAPPING, 2014, 35 (11) :5356-5367

[8] Hypermethylation in the ZBTB20 gene is associated with major depressive disorder [J].

Davies, Matthew N. ;

Krause, Lutz ;

Bell, Jordana T. ;

Gao, Fei ;

Ward, Kirsten J. ;

Wu, Honglong ;

Lu, Hanlin ;

Liu, Yuan ;

Tsai, Pei-Chein ;

Collier, David A. ;

Murphy, Therese ;

Dempster, Emma ;

Mill, Jonathan ;

Battle, Alexis ;

Mostafavi, Sara ;

Zhu, Xiaowei ;

Henders, Anjali ;

Byrne, Enda ;

Wray, Naomi R. ;

Martin, Nicholas G. ;

Spector, Tim D. ;

Wang, Jun .

GENOME BIOLOGY, 2014, 15 (04)

[9] Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression [J].

Dempster, Emma L. ;

Wong, Chloe C. Y. ;

Lester, Kathryn J. ;

Burrage, Joe ;

Gregory, Alice M. ;

Mill, Jonathan ;

Eley, Thalia C. .

BIOLOGICAL PSYCHIATRY, 2014, 76 (12) :977-983

[10] Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding [J].

Denny, WB ;

Valentine, DL ;

Reynolds, PD ;

Smith, DF ;

Scammell, JG .

ENDOCRINOLOGY, 2000, 141 (11) :4107-4113

← 1 2 3 4 5 6 →