Group IB secretory phospholipase A2 induces cell death in the cultured cortical neurons:: a possible involvement of its binding sites

被引：27

作者：

Yagami, T ^{[1
]}

Ueda, K ^{[1
]}

Asakura, K ^{[1
]}

Hata, S ^{[1
]}

Kuroda, T ^{[1
]}

Sakaeda, T ^{[1
]}

Kishino, J ^{[1
]}

Sakaguchi, G ^{[1
]}

Itoh, N ^{[1
]}

Hori, Y ^{[1
]}

机构：

[1] Shionogi & Co Ltd, Discovery Res Labs, Fukushima Ku, Osaka 5530002, Japan

来源：

BRAIN RESEARCH | 2002年 / 949卷 / 1-2期

关键词：

group IB secretory phospholipase A(2); neuronal cell death; high affinity binding site; cortical neuron;

D O I：

10.1016/S0006-8993(02)03144-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In primary cultures of rat cortical neurons, group IB secretory phospholipase A(2) (sPLA(2)-IB) induced cell death. In rat cortical membranes, there were high affinity binding sites of [I-125]sPLA(2)-IB. The high-affinity binding sites were decreased by sPLA(2)-IB and C anti-sPLA(2) receptor immunoglobulin G (anti-sPLA(2)R IgG). Furthermore, anti-sPLA(2)R IgG caused neuronal cell death in a concentration- dependent manner. The present study suggests that sPLA(2)-IB induces neuronal cell death via its high-affinity binding sites. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：197 / 201

页数：5

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