Use of Cardiac Output to Improve Measurement of Input Function in Quantitative Dynamic Contrast-Enhanced MRI

被引:32
作者
Zhang, Jeff L. [1 ]
Rusinek, Henry [1 ]
Bokacheva, Louisa [1 ]
Chen, Qun [1 ]
Storey, Pippa [1 ]
Lee, Vivian S. [1 ]
机构
[1] NYU, Sch Med, Dept Radiol, New York, NY 10003 USA
关键词
cardiac output; dynamic contrast-enhanced MRI; arterial input function; FAST GRADIENT-ECHO; MAGNETIC-RESONANCE; IN-VIVO; CARDIOVASCULAR APPLICATIONS; TUMOR ANGIOGENESIS; T-1; MEASUREMENT; RENAL-FUNCTION; PORCINE MODEL; BLOOD-FLOW; DCE-MRI;
D O I
10.1002/jmri.21891
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To validate a new method for converting MR arterial signal intensity versus time curves to arterial input functions (AIFs). Materials and Methods: The method constrains AIF with patient's cardiac output (Q). Monte Carlo simulations of MR renography and tumor perfusion protocols were carried out for comparison with two alternative methods: direct measurement and population-averaged input function. MR renography was performed to assess the method's inter- and intraday reproducibility for renal parameters. Results: In simulations of tumor perfusion, the precision of the parameters (K(trans) and v(e)) computed using the proposed method was improved by at least a factor of three compared to direct measurement. Similar improvements were obtained in simulations of MR renography. Volunteer study for testing interday reproducibility confirmed the improvement of precision in renal parameters when using the proposed method compared to conventional methods. In another patient study (two injections within one session), the proposed method significantly increased the correlation coefficient (R) between GFR of the two exams (0.92 vs. 0.83) compared to direct measurement. Conclusion: A new method significantly improves the precision of dynamic contrast-enhanced (DCE) parameters. The method may be especially useful for analyzing repeated DCE examinations, such as monitoring tumor therapy or angiotensin converting enzyme-inhibitor renography. Key Words: cardiac output; dynamic contrast-enhanced MRI; arterial input function
引用
收藏
页码:656 / 665
页数:10
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