Kawasaki disease in adults: Observations in France and literature review

被引：42

作者：

Fraison, Jean-Baptiste ^{[1
]}

Seve, Pascal ^{[2
]}

Dauphin, Claire ^{[3
]}

Mahr, Alfred ^{[1
]}

Gomard-Mennesson, Emeline ^{[4
]}

Varron, Loig ^{[5
]}

Pugnet, Gregory ^{[6
]}

Landron, Cedric ^{[7
]}

Roblot, Pascal ^{[7
]}

Oziol, Eric ^{[4
]}

Chalhoub, Gihane ^{[8
]}

Galempoix, Jean-Marc ^{[9
]}

Humbert, Sebastien ^{[10
]}

Humbert, Philippe ^{[11
]}

Sbidian, Emilie ^{[12
]}

Grange, Florent ^{[13
]}

Bayrou, Olivier ^{[14
]}

Cathebras, Pascal ^{[15
]}

Morlat, Philippe ^{[16
]}

Epaulard, Olivier ^{[17
]}

Pavese, Patricia ^{[17
]}

Du Le Thi Huong ^{[18
]}

Zoulim, Abdelkader ^{[19
]}

Stankovic, Katia ^{[20
]}

Bachelez, Herve ^{[21
]}

Smail, Amar ^{[22
]}

Bachmeyer, C. ^{[23
]}

Granel, Brigitte ^{[24
]}

Serratrice, Jacques ^{[24
]}

Brinchault, Graziella ^{[25
]}

Mekinian, Arsene ^{[26
]}

Costedoat-Chalumeau, Nathalie ^{[27
]}

Bourgarit-Durand, Anne ^{[28
]}

Puechal, Xavier ^{[27
]}

Guillevin, Loic ^{[27
]}

Piram, Maryam ^{[29
]}

Kone-Paut, Isabelle ^{[29
]}

Fain, Olivier ^{[26
]}

机构：

[1] Univ Diderot, AP HP, Hop St Louis, Serv Med Interne, F-75010 Paris, France

[2] Univ Lyon, Ctr Hosp Univ Lyon, Hop Croix Rousse, Serv Med Interne, Lyon, France

[3] Univ Clermont Ferrand 2, Serv Cardiol, Hop Gabriel Montpied, F-63006 Clermont Ferrand, France

[4] Ctr Hosp Beziers, Serv Med Interne, Beziers, France

[5] Ctr Hosp Montelimar, Serv Med Interne, Montelimar, France

[6] Ctr Hosp Univ Toulouse, Serv Med Interne, Toulouse, France

[7] Ctr Hosp Univ Poitiers, Serv Med Interne & Malad Infectieuses, Poitiers, France

[8] Ctr Hosp Metz Thionville, Serv Med Interne, Metz, France

[9] Ctr Hosp Charleville Mezieres, Serv Med Interne, Mezieres, France

[10] Ctr Hosp Univ Besancon, Serv Med Interne, Besancon, France

[11] Univ Franche Comte, SFR FED IBCT 4234, INSERM UMR1098, Ctr Hosp Univ Besancon,Serv Dermatol, F-25030 Besancon, France

[12] Univ Paris Est, AP HP, Hop Henri Mondor, Serv Dermatol, Paris, France

[13] Ctr Hosp Univ Reims, Serv Dermatol, Reims, France

[14] Univ Paris 06, AP HP, Hop Tenon, Serv Dermatol, F-75252 Paris 05, France

[15] Ctr Hosp Univ St Etienne, Serv Med Interne, St Etienne, France

[16] Ctr Hosp Univ Bordeaux, Serv Med Interne & Malad Infectieuses, Bordeaux, France

[17] Ctr Hosp Univ Grenoble, Serv Malad Infectieuses, Grenoble, France

[18] Univ Paris 06, AP HP, Hop La Pitie Salpetriere, Serv Med Interne 2, F-75252 Paris 05, France

[19] Ctr Hosp Univ Caen, Serv Med Interne, Caen, France

[20] Univ Paris 06, AP HP, Hop Tenon, Serv Med Interne, F-75252 Paris 05, France

[21] Univ Diderot, AP HP, Hop St Louis, Serv Dermatol, Paris, France

[22] Ctr Hosp Univ dAmiens, Serv Med Interne, Amiens, France

[23] Ctr Hosp Creil, Serv Med Interne, Creil, France

[24] Hop Nord, AP HM, Serv Med Interne, Montpellier, France

[25] Ctr Hosp Univ Rennes, Serv Pneumol, Rennes, France

[26] Univ Paris 06, AP HP, Hop St Antoine, DHUi2B,Serv Med Interne, F-75252 Paris 05, France

[27] Univ Paris 05, AP HP, Ctr Reference Malad Syst& Autoimmunes Rares, Serv Med Interne,Hop Cochin, Paris, France

[28] Univ Leonard Vinci, AP HP, Hop Jean Verdier, Serv Med Interne, Paris, France

[29] Univ Paris Sud, AP HP, Hop Bicetre,Serv Rhumatol Pediat, Ctr Reference Malad Autoinflammatoires Enfant, Paris, France

来源：

AUTOIMMUNITY REVIEWS | 2016年 / 15卷 / 03期

关键词：

Mucocutaneous lymph node syndrome; Adult; Intravenous immunoglobulin; LYMPH-NODE SYNDROME; HUMAN-IMMUNODEFICIENCY-VIRUS; INTRAVENOUS GAMMA-GLOBULIN; CORONARY-ARTERY ANEURYSMS; EPSTEIN-BARR-VIRUS; YOUNG-ADULT; CARDIOVASCULAR-DISEASE; HIV-INFECTION; PERINEAL RASH; PATIENT;

D O I：

10.1016/j.autrev.2015.11.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: Kawasaki disease (KD) is a vasculitis that mostly occurs in young children and rarely in adults. We analyzed the characteristics of adult-onset RD (AKD) in France. Methods: We collected retrospective and prospective data for patients with a diagnosis of RD occurring after the age of 18 years. Cases were obtained via various French medical networks and identified from the international literature. Results: We included 43 patients of AKD at 26 institution from 1992 to 2015, with mean (SD) age 30 (11) years (range 18-68) and sex ratio (M/F) 1.2; 34 patients met the American Heart Association criteria and 9 were incomplete AKD. The median time to diagnosis was 13 days (interquartile range 8-21). The main symptoms were fever (100%), exanthema (98%), changes in the extremities (91%), conjunctivitis (77%), oral cavity changes (89%), cervical adenitis (55%) and cardiac abnormalities (45%). Overall, 35% of patients showed large-vessel vasculitis: coronary vasculitis (26%) and coronary aneurysm (19%). Treatment was mostly intravenous immunoglobulins (79%) and aspirin (81%). Four patients showed myocardial infarction due to coronary vasculitis, but none were treated with Mg because of late diagnosis. After a median follow-up of 5 months (range 1-117), persistent aneurysm was noted in 9% of cases. Damage was significantly lower with early treatment than late or no treatment (p = 0.01). Conclusion: Given the high frequency of cardiac involvement and complications in this series of AKD, diagnosis and treatment should not be delayed, and early IVIg treatment seems to improve the outcome. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：242 / 249

页数：8

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