Immunotherapy Not Working? Check Your Microbiota

被引：49

作者：

West, Nathan R. ^{[1
]}

Powrie, Fiona ^{[1
,2
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford OX3 7LF, England

[2] Univ Oxford, John Radcliffe Hosp, Div Expt Med, Translat Gastroenterol Unit, Oxford OX3 9DU, England

来源：

CANCER CELL | 2015年 / 28卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

BLOCKADE; IMMUNITY; CTLA-4;

D O I：

10.1016/j.ccell.2015.11.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gut microbes have ascended to prominence as key modulators of host immunity, raising the possibility that they could influence the outcome of cancer immunotherapy. Two recent studies address this question by identifying specific gut-resident bacteria as drivers of checkpoint blockade immunotherapy in pre-clinical tumor models.

引用

页码：687 / 689

页数：3

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