National Cancer Institute Basket/Umbrella Clinical Trials MATCH, LungMAP, and Beyond

被引：17

作者：

Chen, Alice P. ^{[1
]}

Eljanne, Mariam ^{[2
]}

Harris, Lyndsay ^{[3
]}

Malik, Shakuntala ^{[4
]}

Seibel, Nita L. ^{[4
]}

机构：

[1] NCI, Div Canc Treatment & Diag, Early Clin Trials Dev Program, Bethesda, MD 20892 USA

[2] NCI, Div Canc Biol, Bethesda, MD 20892 USA

[3] NCI, Canc Diag Program, Div Canc Res & Diag, Bethesda, MD 20892 USA

[4] NCI, Canc Therapy Evaluat Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

来源：

CANCER JOURNAL | 2019年 / 25卷 / 04期

关键词：

ALCHEMIST; ALK; LungMAP; MPACT; NCI-MATCH; Pediatric MATCH; precision medicine; ANALYTICAL VALIDATION; MOLECULAR-ANALYSIS; BIOMARKERS; ASSAY;

D O I：

10.1097/PPO.0000000000000389

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With advances in genetic testing and its common usage, the field of precision medicine has exploded in the field of oncology. The National Cancer Institute is uniquely positioned to lead in this area of research through its wide network of investigators, partnerships with pharmaceutical companies in drug development, and laboratory capabilities. It has developed a portfolio of trials as part of a Precision Medicine Initiative that uses various basket/umbrella designs to increase the understanding of treatment of cancer through genetic selection and targeted therapies. This article describes these trials, ALCHEMIST, LungMAP, NCI/NRG ALK Trial, MPACT, NCI-MATCH, and pediatric MATCH, and their contributions to the area of precision medicine.

引用

页码：272 / 281

页数：10

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