Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2-/-γc-/- Mouse

被引：60

作者：

Choudhary, Shailesh K. ^{[1
]}

Rezk, Naser L. ^{[2
]}

Ince, William L. ^{[3
]}

Cheema, Manzoor ^{[1
]}

Zhang, Liguo ^{[4
]}

Su, Lishan ^{[3
,4
]}

Swanstrom, Ronald ^{[3
]}

Kashuba, Angela D. M. ^{[2
]}

Margolis, David M. ^{[1
,4
,5
]}

机构：

[1] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Pharm, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 16期

关键词：

IN-VITRO; ANTIRETROVIRAL THERAPY; RHESUS MACAQUES; MICE; INFECTION; TRANSMISSION; TENOFOVIR; EMTRICITABINE; REPLICATION; RALTEGRAVIR;

D O I：

10.1128/JVI.00580-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A small animal model that reproduces human immunodeficiency virus type 1 (HIV-1) pathogenesis may allow modeling of new therapeutic strategies in ways not approachable in mononuclear cell culture. We find that, as in humans, combination antiretroviral therapy (ART) in humanized (hu-) Rag2(-/-)gamma(-/-)(c) mice allows suppression of viremia below the limits of detection and recovery of CD4(+) cells, while interruption of ART results in viral rebound and renewed loss of CD4(+) T cells. Failure of ART in infected mice is associated with the appearance of drug resistance mutations. The hu-Rag2(-/-)gamma(-/-)(c) mouse may therefore facilitate testing of novel approaches to HIV replication and persistence.

引用

页码：8254 / 8258

页数：5

共 42 条

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[42] Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels
Pal, R
Venzon, D
Santra, S
Kalyanaraman, VS
Montefiori, DC
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JOURNAL OF VIROLOGY, 2006, 80 (08) : 3732 - 3742

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