Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4+ T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2-/-γc-/- Mouse

被引：60
|
作者：
Choudhary, Shailesh K. [1 ]
Rezk, Naser L. [2 ]
Ince, William L. [3 ]
Cheema, Manzoor [1 ]
Zhang, Liguo [4 ]
Su, Lishan [3 ,4 ]
Swanstrom, Ronald [3 ]
Kashuba, Angela D. M. [2 ]
Margolis, David M. [1 ,4 ,5 ]
机构：
[1] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Pharm, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
[5] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF VIROLOGY | 2009年 / 83卷 / 16期
关键词：
IN-VITRO; ANTIRETROVIRAL THERAPY; RHESUS MACAQUES; MICE; INFECTION; TRANSMISSION; TENOFOVIR; EMTRICITABINE; REPLICATION; RALTEGRAVIR;
D O I：
10.1128/JVI.00580-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A small animal model that reproduces human immunodeficiency virus type 1 (HIV-1) pathogenesis may allow modeling of new therapeutic strategies in ways not approachable in mononuclear cell culture. We find that, as in humans, combination antiretroviral therapy (ART) in humanized (hu-) Rag2(-/-)gamma(-/-)(c) mice allows suppression of viremia below the limits of detection and recovery of CD4(+) cells, while interruption of ART results in viral rebound and renewed loss of CD4(+) T cells. Failure of ART in infected mice is associated with the appearance of drug resistance mutations. The hu-Rag2(-/-)gamma(-/-)(c) mouse may therefore facilitate testing of novel approaches to HIV replication and persistence.
引用
收藏
页码：8254 / 8258
页数：5
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