Target-controlled propofol requirements at induction of anaesthesia: effect of remifentanil and midazolam

被引:15
作者
Conway, DH [1 ]
Hasan, SK [1 ]
Simpson, ME [1 ]
机构
[1] Manchester Royal Infirm, Dept Anaesthesia, Manchester M13 9WL, Lancs, England
关键词
anaesthesia; intravenous; anaesthetics; propofol; remifentanil; midazolam; drug interactions; drug synergism;
D O I
10.1017/S0265021502000935
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background and objective: Target-controlled infusions of anaesthetic agents have become increasingly available. They can involve the use of propofol in combination with an opioid or a benzodiazepine. The effect site concentration of propofol infusions has been advocated as a method of estimating drug distribution. We investigated the influence of co-induction with remifentanil and midazolam on effect site propofol requirements at induction of anaesthesia using target-controlled infusions. Methods: Sixty-six consenting adult patients were randomly allocated to three treatment groups. Each group received induction of anaesthesia with a different total intravenous technique. One group was induced with target-controlled propofol alone; another received target-controlled propofol and target-controlled remifentanil (3 ng mL(-1)); and the last received midazolam (0.03 mg kg(-1)), target-controlled remifentanil (3 ng mL(-1)) and target-controlled propofol. Computer simulation was used to calculate effect site concentrations. We recorded propofol dose and effect site concentration at loss of verbal response. Results: The effect site concentration (C-e50) of propofol alone was 2.19 mug mL(-1). This was reduced to 1.55 mug mL(-1) during co-induction with remifentanil and further reduced to 0.64 mug mL(-1) with midazolam premedication (P < 0.001; ANOVA). Conclusions: We conclude that co-induction with remifentanil alone or with midazolam can be used to reduce propofol doses at induction of anaesthesia using target-controlled infusions. We believe that using effect site concentration may prove a useful tool in routine clinical practice.
引用
收藏
页码:580 / 584
页数:5
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