Pathogenesis of aplastic anemia

被引：79
作者：
Wang, Li [1 ]
Liu, Hong [1 ]
机构：
[1] Nantong Univ, Dept Hematol, Affiliated Hosp, Nantong, Peoples R China
来源：
HEMATOLOGY | 2019年 / 24卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Hematology; aplastic anemia; hematopoietic stem cells; mesenchymal stem cells; immune function; HLA; clonal hematopoiesis; telomere; HEMATOPOIETIC STEM-CELLS; BONE-MARROW FAILURE; T-CELLS; INTERFERON-GAMMA; TELOMERE LENGTH; IN-VIVO; CLONAL HEMATOPOIESIS; SOMATIC MUTATIONS; IMMUNE-RESPONSES; PROGENITOR CELLS;
D O I：
10.1080/16078454.2019.1642548
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation. The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated. The pathogenesis of AA is complex and its mechanism needs to be deciphered on an individualized basis. This review summarizes several contributions made in trying to understand AA pathogenesis in recent years which may be helpful for the development of personalized therapies for AA.
引用
收藏
页码：559 / 566
页数：8
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